143585-30-2Relevant academic research and scientific papers
Chelate-Controlled Mukaiyama Reactions with Chiral β-Formyl Esters
Angert, Hubert,Kunz, Thomas,Reissig, Hans-Ulrich
, p. 5681 - 5690 (2007/10/02)
Additions of silyl enol ethers 3, 6, and 8 to chiral β-formyl esters 1 in the presence of TiCl4 provide trans-γ-lactones 4, 7, and 9 in high yield and with good to excellent diastereofacial selectivity.This high trans-preferrence is due to effective chelate-control involving seven-membered ring 1-TiCl4 complexes.
