1435933-04-2

Usage

Uses

Used in Sun Protection Products:
Tert-butyl 4-hydroxy-2-methoxyphenylcarbamate is used as a UV filter in sun protection products for its ability to absorb and block UV radiation, protecting the skin from sunburn and other forms of sun damage. Its stability and resistance to degradation make it a valuable ingredient in sunscreen formulations.
Used in Cosmetic Industry:
In the cosmetic industry, tert-butyl 4-hydroxy-2-methoxyphenylcarbamate is used as a UV filter in various cosmetic products to provide protection against harmful UV rays, ensuring the safety and well-being of the skin. Its inclusion in these products helps to prevent skin damage and premature aging caused by sun exposure.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 37966-57-7 4-amino-3-methoxyphenol hydrochloride 
• 1470110-81-6 acetic acid 4-tert-butoxycarbonylamino-3-methoxyphenyl ester 
• 49698-84-2 acetic acid 4-amino-3-methoxyphenyl ester 
• 49698-82-0 acetic acid 3-methoxy-4-nitrophenyl ester 
• 16292-95-8 4-nitro-3-methoxyphenol 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 446-36-6 5-fluoro-2-nitrophenol 

Downstream Products

• 1470111-36-4 C₄₁H₄₇NO₁₁ 

Relevant academic research and scientific papers

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

The carbonate analogues of 5′-halogenated resiniferatoxin as TRPV1 ligands

A series of carbonate analogues of 5′-halogenated RTX have been investigated in order to examine the effect of the carbonate group as a linker and the role of halogens in the reversal of activity from agonism to antagonism for rat and human TRPV1 heterologously expressed in Chinese hamster ovary cells. The carbonate analogues showed similar activities to the corresponding RTX derivatives in rat TRPV1 but lower potency in human TRPV1. 5-Halogenation converted the agonists to partial agonists or full antagonists and the extent of antagonism reflected the order of I > Br > Cl > F, with a somewhat greater extent of antagonism for the derivatives of the 4-amino RTX surrogates compared to the corresponding derivatives of RTX itself. The carbonate analogues of I-RTX (60) and 5-bromo-4-amino-RTX (66) were potent and full antagonists with Ki(ant) = 2.23 and 2.46 nM, respectively, for rat TRPV1, which were ca. 5-fold more potent than I-RTX (2) under our conditions. The conformational analysis of the I-RTX-carbonate (60) indicated that its bent conformation was similar to that of I-RTX, consistent with compound 60 and I-RTX showing comparable potent antagonism.