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1435933-46-2

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1435933-46-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1435933-46-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,5,9,3 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1435933-46:
(9*1)+(8*4)+(7*3)+(6*5)+(5*9)+(4*3)+(3*3)+(2*4)+(1*6)=172
172 % 10 = 2
So 1435933-46-2 is a valid CAS Registry Number.

1435933-46-2Relevant academic research and scientific papers

Discovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives

Takahashi, Eiki,Hirano, Noriyuki,Nagahara, Takashi,Yoshikawa, Satoru,Momen, Shinobu,Yokokawa, Hiroshi,Hayashi, Ryoji

, p. 3154 - 3156 (2013/06/26)

We aimed to discover a novel type of transient receptor potential vanilloid 1 (TRPV1) antagonist because such antagonists are possible drug candidates for treating various disorders. We modified the structure of hit compound 7 (human TRPV1 IC50 = 411 nM) and converted its pyrrolidino group to a (hydroxyethyl)methylamino group, which substantially improved inhibitory activity (15d; human TRPV1 IC50 = 33 nM). In addition, 15d ameliorated bladder overactivity in rats in vivo.

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