1878-55-3

Usage

Uses

Used in Agricultural and Horticultural Applications:
[3-(1,1-dimethylethyl)phenoxy]acetic acid is used as a herbicide for controlling unwanted vegetation, including weeds. It functions by inhibiting the synthesis of plant cell walls, which ultimately leads to the death of the targeted plants. Its low toxicity to mammals makes it a preferred choice in these settings.
However, it is crucial to handle and use this chemical with caution, as improper or excessive exposure can still pose potential health risks. [3-(1,1-dimethylethyl)phenoxy]acetic acid's effectiveness in controlling unwanted vegetation, coupled with its relatively low toxicity to mammals, has led to its widespread use in agricultural and horticultural practices.

InChI:InChI=1/C12H16O3/c1-12(2,3)9-5-4-6-10(7-9)15-8-11(13)14/h4-7H,8H2,1-3H3,(H,13,14)

Upstream product

• 585-34-2 3-tert-butylphenyol 
• 1435933-46-2 C₁₆H₂₄O₃ 

Downstream Products

• 25441-21-8 2-(3-tert-Butyl-phenoxy)-N-methylcarbamoylmethyl-acetamide 
• 1435933-34-8 C₂₀H₂₇N₃O₃ 
• 25441-22-9 2-(3-tert-Butyl-phenoxy)-N-dimethylcarbamoylmethyl-acetamide 

Relevant academic research and scientific papers

Radical decarboxylative fluorination of aryloxyacetic acids using N-fluorobenzenesulfonimide and a photosensitizer

Fluorinated methoxy arenes are emerging as important motifs in both agrochemicals and pharmaceuticals. A novel technique for the synthesis of monofluoromethoxy arenes through the direct fluorodecarboxylation of carboxylic acids was developed that uses photosensitizers and N-fluorobenzenesulfonimide (NFSI). Utilization of the oxidatively mild fluorine transfer agent NFSI enabled the synthesis of fluoromethyl ethers that were previously inaccessible with decarboxylative fluorinations performed with Selectfluor. Mechanistic studies are consistent with the photosensitizer effecting oxidation of the aryloxyacetic acid.

Discovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives

We aimed to discover a novel type of transient receptor potential vanilloid 1 (TRPV1) antagonist because such antagonists are possible drug candidates for treating various disorders. We modified the structure of hit compound 7 (human TRPV1 IC50 = 411 nM) and converted its pyrrolidino group to a (hydroxyethyl)methylamino group, which substantially improved inhibitory activity (15d; human TRPV1 IC50 = 33 nM). In addition, 15d ameliorated bladder overactivity in rats in vivo.