1435946-91-0Relevant academic research and scientific papers
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors
Xiao, Dong,Palani, Anandan,Huang, Xianhai,Sofolarides, Michael,Zhou, Wei,Chen, Xiao,Aslanian, Robert,Guo, Zhuyan,Fossetta, James,Tian, Fang,Trivedi, Prashant,Spacciapoli, Peter,Whitehurst, Charles E.,Lundell, Daniel
, p. 3262 - 3266 (2013/06/27)
Conformation restriction of linear N-alkylanilide MK2 inhibitors to their E-conformer was developed. This strategy enabled rapid advance in identifying a series of potent non-ATP competitive inhibitors that exhibited cell based activity in anti-TNFα assay.
