299203-59-1

Upstream product

• 52938-94-0 5-(4-cyanophenyl)furan-2-carboxylic acid 
• 64-17-5 ethanol 
• 6132-37-2 ethyl 5-bromofuran-2-carboxylate 
• 3058-39-7 4-iodobenzonitrile 
• 623-00-7 4-bromobenzenecarbonitrile 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 1312578-81-6 C₂₃H₂₀N₄O₂ 
• 1357089-54-3 C₃₁H₂₆N₄O₄ 
• 1357089-53-2 C₃₃H₃₂N₄O₅ 
• 1312578-88-3 C₃₄H₂₈N₆O₂ 
• 1435946-91-0 C₃₆H₃₁N₅O₃ 
• 1435946-90-9 C₃₆H₃₁N₅O₃ 
• 1435946-89-6 C₃₅H₂₉N₅O₂ 
• 1435946-88-5 C₃₆H₃₁N₅O₃ 
• 1435946-87-4 C₃₅H₂₈FN₅O₂ 
• 1435946-86-3 C₃₆H₂₉FN₄O₂ 
• 1449511-56-1 C₃₈H₃₁BrN₄O₄ 
• 1357089-49-6 C₃₃H₃₀N₄O₈ 

Relevant academic research and scientific papers

NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present disclosure relates to a novel compound and a pharmaceutical composition comprising the same. The compound according to the present disclosure has effects for activating autophagy, and thus can be valuably used for preventing or treating diseas

PROCESS FOR MAKING ORGANOBORON COMPOUNDS, PRODUCTS OBTAINABLE THEREBY, AND THEIR USE

A process for making organoboron compounds is disclosed in which at least one organic compound having at least one Cl, Br, or I atom or at least one nucleophilic leaving group substituent is reacted with at least one boron-containing reagent represented by the chemical formula (IA) or (IB): B(YR1)3 (IA) [Cat]n+[B(YR1)4-]n (IB) in the presence of at least one oxidizable metal or oxidizable metal complex, wherein each Y independently represents an oxygen atom, a sulfur atom, or NR-, each R1 and each R independently represents an organic moiety comprising up to 15 carbon atoms and, optionally, one or more hetero atoms, Cat is a cation or mixture of cations, and n is a positive number in the range from 1 to 3. The organoboron products obtained by this process are useful for conducting coupling reactions and reactions with aldehydes. Due to their selectivity, such reactions may be conducted in protic solvents, such as water and alcohols, and sensitive functional groups in the reactants are maintained in the final product. The organoboron products are stable, so that they maintain their activity during storage.

Efficient synthesis of functionalized organozinc compounds by the direct insertion of zinc into organic iodides and bromides

(Chemical Equation Presented) Insider dealing: A wide range of poly-functional (hetero)aromatic and aliphatic zinc reagents can be easily prepared in THF. The compounds are formed by a Zn insertion reaction mediated by the addition of LiCl (see scheme; All = allyl).

Aromatic extended bisamidines: Synthesis, inhibition of topoisomerases, and anticancer cytotoxicity in vitro

A series of four aromatic extended bisamidines (12-15) differing in the nature of their terminal basic side chains were synthesized and evaluated for cytotoxic activity in MCF-7 cultured breast cancer cells. The concentrations of 12, 13, 14, and 15 needed to inhibit [3H]thymidine incorporation into DNA by 50% (IC50) were found to be 63 μM, 85 μM, 77 μM, and 97 μM, respectively. To test whether cytotoxic properties were related to DNA-binding and topoisomerase action, the bisamidines 12-15 were evaluated in a cell-free system. Data from the ethidium displacement assay showed that bisamidines 12-15 have significant affinity for DNA and show moderate specificity for AT base pairs. In the topoisomerase II assay, the relaxation of DNA was inhibited with all four drugs and the extent of inhibition was directly proportional to the drug concentration. This suggests that DNA binding may be implicated in the cytotoxicity of these bisamidines, possibly by inhibiting interactions between topoisomerase II and their DNA targets.