143602-78-2Relevant academic research and scientific papers
Synthesis of Highly Substituted Polyenes by Palladium-Catalyzed Cross–Couplings of Sterically Encumbered Alkenyl Bromides and N-Tosylhydrazones
Paraja, Miguel,Barroso, Raquel,Cabal, M. Paz,Valdés, Carlos
, p. 1058 - 1062 (2017)
A new method for the synthesis of polysubstituted conjugated dienes is described, through the palladium-catalyzed cross-coupling between N-tosylhydrazones and alkenyl bromides. The reaction proceeds efficiently when a combination of a highly substituted bromoalkene and a hydrazone derived from a ketone are employed, pointing to the convenience of a sterically encumbered environment. This unprecedented process allows for the stereocontrolled preparation of highly substituted dienes and polyenes. (Figure presented.).
