143604-04-0Relevant articles and documents
Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: wherein X, Ar1, R2-R6 and R12 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
New indole and triazino[5,4-b]indol-4-one derivatives: Synthesis and studies as inotropics and inhibitors of blood platelet aggregation
Monge,Aldana,Font,Arraras,Santiago,Lopez-Unzu,Martinez de Irujo,Alberdi
, p. 439 - 452 (2007/10/02)
New triazino[5,4b]indol-4-one derivatives carrying amino groups in position 3 were synthetized and tested as inotropic agents and inhibitors of platelet aggregation 2h, 2p, 5p, and 6g are the most active as inotropic agents. Compounds were tested as inhib