1436383-75-3Relevant academic research and scientific papers
Successive regioselective metalations of fused heterocycles: Synthesis of polyfunctionalized furo[3,2- b ]pyridines
Jasselin-Hinschberger, Adeline,Comoy, Corinne,Chartoire, Anthony,Fort, Yves
, p. 5618 - 5626 (2013)
The furopyridine framework was chosen as a target for a lithiation study, in order to define the most effective conditions leading to the total functionalization of the heterocycle. Consequently, a detailed procedure for successive regioselective lithiations/electrophilic trapping of furo[3,2-b]pyridines is described and afforded several polyfunctionalized derivatives in good overall yields. A Pd-catalyzed cross-coupling reaction is also described and easily yielded the 7,7′-bifuro[3,2-b]pyridine.
