1436385-59-9Relevant academic research and scientific papers
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins
Dana, Dibyendu,Davalos, Anibal R.,De, Shatarupa,Rathod, Pratikkumar,Gamage, Ranjith K.,Huestis, Juliana,Afzal, Nisar,Zavlanov, Yuriy,Paroly, Suneeta S.,Rotenberg, Susan A.,Subramaniam, Gopal,Mark, Kevin J.,Chang, Emmanuel J.,Kumar, Sanjai
, p. 2975 - 2987 (2013)
Cysteine cathepsins are an important class of enzymes that coordinate a variety of important cellular processes, and are implicated in various types of human diseases. However, small molecule inhibitors that are cell-permeable and non-peptidyl in nature are scarcely available. Herein the synthesis and development of sulfonyloxiranes as covalent inhibitors of cysteine cathepsins are reported. From a library of compounds, compound 5 is identified as a selective inhibitor of cysteine cathepsins. Live cell imaging and immunocytochemistry of metastatic human breast carcinoma MDA-MB-231 cells document the efficacy of compound 5 in inhibiting cysteine cathepsin activity in living cells. A cell-motility assay demonstrates that compound 5 is effective in mitigating the cell-migratory potential of highly metastatic breast carcinoma MDA-MB-231 cells.
