1436408-33-1Relevant articles and documents
Launching spiking ligands into a protein-protein interface: A promising strategy to destabilize and break interface formation in a tRNA modifying enzyme
Immekus, Florian,Barandun, Luzi Jakob,Betz, Michael,Debaene, Francois,Petiot, Stephanie,Sanglier-Cianferani, Sarah,Reuter, Klaus,Diederich, Francois,Klebe, Gerhard
, p. 1163 - 1178 (2013/07/26)
Apart from competitive active-site inhibition of protein function, perturbance of protein-protein interactions by small molecules in oligodomain enzymes opens new perspectives for innovative therapeutics. tRNA-guanine transglycosylase (TGT), a potential t