1436412-05-3Relevant articles and documents
Total synthesis of (-)-hippodamine by stereocontrolled construction of azaphenalene skeleton based on extended one-pot asymmetric azaelectrocyclization
Fujita, Shintaro,Sakaguchi, Taku,Kobayashi, Toyoharu,Tsuchikawa, Hiroshi,Katsumura, Shigeo
, p. 2758 - 2761 (2013/07/19)
The first asymmetric total synthesis of (-)-hippodamine has been accomplished via the concise construction of its azaphenalene core, which is featured by the 2,4,6-chiral piperidine synthesis based on one-pot asymmetric azaelectrocyclization in the partially activated substituent system and the subsequent intramolecular Mannich reaction.