1436415-46-1

Basic information

• Product Name: methyl 2-{6-[(tert-butyldimethylsilyloxy)methyl]-4-oxo-4H-pyran-3-carbonyl}-3,5-dimethoxybenzoate
• Synonyms: methyl 2-{6-[(tert-butyldimethylsilyloxy)methyl]-4-oxo-4H-pyran-3-carbonyl}-3,5-dimethoxybenzoate
• CAS NO: 1436415-46-1
• Molecular Weight: 462.572
• Mol File: 1436415-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-{6-[(tert-butyldimethylsilyloxy)methyl]-4-oxo-4H-pyran-3-carbonyl}-3,5-dimethoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-{6-[(tert-butyldimethylsilyloxy)methyl]-4-oxo-4H-pyran-3-carbonyl}-3,5-dimethoxybenzoate(1436415-46-1)
• EPA Substance Registry System: methyl 2-{6-[(tert-butyldimethylsilyloxy)methyl]-4-oxo-4H-pyran-3-carbonyl}-3,5-dimethoxybenzoate(1436415-46-1)

Safety Data

• Hazardous Substances Data: 1436415-46-1(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 114605-46-8 methyl 2-iodo-3,5-dimethoxybenzoate 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 

Relevant articles and documents

Total syntheses and biological evaluation of 3-O-methylfunicone and its derivatives prepared by TMPZnCl·LiCl-mediated halogenation and carbonylative stille cross-coupling

The total syntheses of the natural product 3-O-methylfunicone (1), a member of the funicone class of compounds, and its derivatives is reported. The key reactions in the construction of the biaryl ketone core are a regioselective TMPZnCl·LiCl halogenation and a carbonylative Stille cross-coupling reaction. In addition, the inhibitory activities of the funicones against Y-family DNA polymerase κ (pol κ) and polymerase η (pol η) were determined. We found that 1 and 12 exhibit inhibitory activity against pol η and 1 also against pol κ. The total syntheses of the natural product 3-O-methylfunicone and its derivatives has been accomplished. The key reactions are TMPZnCl·LiCl-mediated iodination and a carbonylative Stille cross-coupling reaction. In addition, the inhibitory effect of the synthesized compounds have been evaluated against Y-family DNA polymerases κ and η by primer extension experiments. Copyright