1436419-21-4

Basic information

• Product Name: methyl 2-(4-(furan-2-ylmethylene)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetate
• Synonyms: methyl 2-(4-(furan-2-ylmethylene)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetate
• CAS NO: 1436419-21-4
• Molecular Weight: 310.309
• Mol File: 1436419-21-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-(furan-2-ylmethylene)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-(furan-2-ylmethylene)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetate(1436419-21-4)
• EPA Substance Registry System: methyl 2-(4-(furan-2-ylmethylene)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetate(1436419-21-4)

Safety Data

• Hazardous Substances Data: 1436419-21-4(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 100-63-0 phenylhydrazine 
• 105041-27-8 (5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-3-yl)-acetic acid methyl ester 

Relevant articles and documents

Detour of prenostodione synthesis towards pyrazolones for antibacterial activity

Our attempts to prepare indolyl acid (3), enroute to prenostodione (2), from phenyl-hydrazine following a reported procedure of Fischer-Indole synthesis rather lead to ethyl 2-(5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-3-yl)acetate as a major product, which underwent facile condensation with aldehydes to provide the pyrazolones. Intrigued by the opportunity for the diversity oriented synthesis of substituted pyrazolones, we have developed a facile one pot approach for pyrazolones and screened for antibacterial activity and, herein, results are reported.