1436463-10-3

Upstream product

• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 1436463-05-6 1-tert-butyl 2,2-diethyl 3-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-1,2,2-tricarboxylate 
• 13433-00-6 diethyl aminomalonate hydrochloride 
• 1132641-34-9 methyl 2-(((tert-butoxycarbonyl)oxy)(4-methoxyphenyl)methyl)acrylate 
• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 

Relevant academic research and scientific papers

Catalytic asymmetric one-pot synthesis of α-methylene-γ-lactams

An organocatalytic enantioselective synthesis of α-methylene-γ- lactams has been developed. The reaction between protected 2-aminomalonates and Morita-Baylis-Hillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in exce

An efficient synthesis of β,γ,γ-trisubstituted-α- diethoxyphosphoryl-γ-lactams: A convenient approach to α-methylene-γ-lactams

A general and efficient method for the preparation of β,γ, γ-trisubstituted-α-phosphono-γ-lactams is presented for the first time. This approach is based on the Michael addition of diethyl acetamidomalonate to methyl (E)-3-aryl-2-(diethoxyphosphoryl)acrylates. Application of the phosphono-lactams obtained for the preparation of α-methylene-γ-lactams is also reported.