143666-05-1

Basic information

• Product Name: 2-(3-(4-nitrophenoxy)propyl)-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 2-(3-(4-nitrophenoxy)propyl)-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 143666-05-1
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.363
• Mol File: 143666-05-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-(4-nitrophenoxy)propyl)-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(4-nitrophenoxy)propyl)-1,2,3,4-tetrahydroisoquinoline(143666-05-1)
• EPA Substance Registry System: 2-(3-(4-nitrophenoxy)propyl)-1,2,3,4-tetrahydroisoquinoline(143666-05-1)

Safety Data

• Hazardous Substances Data: 143666-05-1(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 13094-50-3 1-(3-bromopropoxy)-4-nitrobenzene 

Downstream Products

• 143666-06-2 4-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-propoxy]-phenylamine 

Relevant articles and documents

Synthesis and Activity against Multidrug Resistance in Chinese Hamster Ovary Cells of New Acridone-4-carboxamides

A number of tricyclic carboxamides have been synthesized and tested to evaluate their ability to reverse multidrug resistance in the CHRC/5 cell line.Among them the acridone derivatives were the most potent.A key feature is the presence of a dimethoxybenzyl or phenethylamine cationic site, separated from the tricyclic lipophilic part by a carbamoylphenyl chain.Optimization led to compounds 2 orders of magnitude more active than the prototype inhibitors verapamil and amiodarone.On the basis of in vitro and in vivo activities, 9,10-dihydro-5-methoxy-9-oxo-N-phenyl>-4-acridinecarboxamide (84) has been selected for further development.