143668-40-0

Upstream product

• 21820-50-8 DL-phenylalanine hydrazide 
• 78-39-7 Triethyl orthoacetate 
• 63-91-2 L-phenylalanine 
• 21820-50-8 2-amino-3-phenylpropionic acid hydrazide 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 15150-71-7 5-benzyl-3-methyl-6-oxo-1,6-dihydro-1,2,4-triazine 

Relevant academic research and scientific papers

Synthesis of novel 1-[(1-ethoxymethylene)amino]imidazol-5(4H)-ones and 1,2,4-triazin-6(5H)-ones from optically active α-aminocarboxylic acid hydrazides

New derivatives of 1-[(1-ethoxymethylene)amino]imidazol-5(4H)-one and 1,2,4-triazin-6(5H)-one were synthesized via reactions of optically active α-aminocarboxylic acid hydrazides and triethyl orthoesters in xylene. The factors influencing the formation of the unexpected five-membered products and attempts to elucidate the mechanism are discussed.

Synthesis of 1,2,4-Triazines, XV. - Synthesis of 1,2,4-Triazin-6(1H)-ones

1,2,4-Triazin-6(1H)-ones 3 have been prepared by cyclization of α-ketoacyl chlorides 15 with amidrazones 14. 4,5-Dihydro-1,2,4-triazin-6(1H)-ones 5 were obtained by cyclization of amino acid hydrazides 10 with orthocarboxylates 11.Key Word: 1,2,4-Triazin-