1436715-69-3

Upstream product

• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 1436715-30-8 N-((6-((tert-butyldimethylsilyl)oxy)cyclohex-1-en-1-yl)methyl)-4-methyl-N-(prop-2-yn-1-yl)-p-toluenesulfonamide 
• 354578-85-1 (6-((tert-butyldimethylsilyl)oxy)cyclohex-1-en-1-yl)methyl acetate 
• 354578-83-9 (6-hydroxycyclohex-1-en-1-yl)methyl acetate 
• 106281-44-1 (6-oxocyclohex-1-en-1-yl)methyl acetate 
• 105956-40-9 2-(hydroxymethyl)cyclohex-2-en-1-one 
• 930-68-7 cyclohexenone 

Downstream Products

• 1436714-11-2 (Z)-ethyl 4-(fluoro(2-tosyl-2,3,4a,5,6,7-hexahydroisoquinolin-4(1H)-ylidene)methyl)benzoate 

Relevant academic research and scientific papers

Transition-metal-free carbofluorination of TBS-protected nitrogen-containing cyclic enynols: Synthesis of fluorinated azabicycles

The synthesis of fluorinated azabicycles from tert-butyldimethylsilyl- protected N-containing cyclic enynols using inexpensive BF3· OEt2 is described. In this reaction, BF3 reacts as both the Lewis acid and the fluoride source for cyclization/fluorination of the TBS-protected cyclic N-containing enynols. The method provides an easy access to fluorinated azabicycles where a new C(sp2)-F bond and a new bicyclic skeleton are generated at ambient temperature within 1-13 min under metal-free reaction conditions.