1436853-06-3Relevant academic research and scientific papers
Rearrangement of 4-amino-3-halo-pyridines by nucleophilic aromatic substitution
Getlik, Matth?us,Wilson, Brian J.,Morshed, M. Monzur,Watson, Iain D. G.,Tang, Doris,Subramanian, Pandiaraju,Al-Awar, Rima
, p. 5705 - 5710 (2013/07/25)
The reaction of 3-halo-4-aminopyridines with acyl chlorides and triethylamine is described. The pyridin-4-yl α-substituted acetamide products were obtained in moderate to high yields. The presented rearrangement reaction, in which the presumed N-acylated intermediate reacts intramolecularly via nucleophilic aromatic substitution, results in a formal two-carbon insertion.
