14369-14-3

Basic information

• Product Name: 6-Chloro-3-Methoxypyridazin-4-aMine
• Synonyms: 6-Chloro-3-Methoxypyridazin-4-aMine;4-aMino-6-chloro-3-Methoxypyridazine
• CAS NO: 14369-14-3
• Molecular Formula: C5H6ClN3O
• Molecular Weight: 159.57364
• Mol File: 14369-14-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 6-Chloro-3-Methoxypyridazin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-3-Methoxypyridazin-4-aMine(14369-14-3)
• EPA Substance Registry System: 6-Chloro-3-Methoxypyridazin-4-aMine(14369-14-3)

Safety Data

• Hazardous Substances Data: 14369-14-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-3-Methoxypyridazin-4-aMine is used as a key intermediate for the synthesis of pyridazine derivatives, which are known to possess a wide range of pharmacological properties. These derivatives have been found to be effective in treating various diseases, including cancer, inflammation, and bacterial infections.
Used in Chemical Industry:
In the chemical industry, 6-Chloro-3-Methoxypyridazin-4-aMine serves as a valuable building block for the development of novel compounds with potential applications in various fields. Its unique structural features allow for further functionalization and modification, leading to the creation of new molecules with improved properties and performance.
Used in Research and Development:
6-Chloro-3-Methoxypyridazin-4-aMine is also utilized in research and development laboratories for the exploration of new synthetic routes and methodologies. Its reactivity and structural diversity make it an attractive candidate for the development of innovative chemical processes and the discovery of new compounds with potential applications in various industries.

Upstream product

• 34127-26-9 6-chloro-3-methoxy-pyridazine-4-carboxylic acid amide 
• 67-56-1 methanol 
• 823-58-5 3,6-dichloropyridazin-4-amine 
• 1722-10-7 3-chloro-6-methoxypyridazine 
• 180284-17-7 4-azido-6-chloro-3-methoxypyridazine 

Downstream Products

• 14704-64-4 5-Amino-3-chloropyridazin-6(1H)-one 
• 14369-21-2 5-amino-6-methoxy-3(2H)-pyridazinone 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

PYRIDAZINIL QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF TUMOURS

The invention concerns quinazoline derivatives of Formula (I) wherein Z is an O, S, SO, SO2, N(R2) or C(R2)(R3) group wherein each R2 or R3 group is hydrogen or (1-8C)alkyl, m is 1, 2 or 3, each R1 group has any of the meanings defined in the description, Ra is halogeno or (1-6C)alkoxy, Rb is halogeno or (1-6C)alkoxy, and Rc is hydrogen, halogeno, (1-8C)alkyl or (1-6C)alkoxy, or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.

A new route to aminodiazines via metalation reaction. Synthesis of an aza analogue of Nevirapine: Diazines XV

A new route to aminodiazines is reported, the ortho-directed lithiation of diazines is used, followed by reaction with tosyl azide as an electrophile. The reduction of the azido or tetrazolo compounds obtained was achieved and led to the expected amines. This methodology has allowed the synthesis of new aminodiazines and an improvement in the yield of various aminodiazines previously described. This reaction was used for the preparation of an aza analogue of Nevirapine.