143697-66-9Relevant academic research and scientific papers
Synthesis and renal vasodilator activity of substituted [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic acids
Russell,Appollina,Bandurco,Combs,Kanojia,Mallory,Malloy,McNally,Mulvey,Gray-Nunez,Rampulla,Rampulla,Sisk,Williams,Levine,Bell,Giardino,Falotico,Tobia
, p. 277 - 284 (1992)
The synthesis and cardiovascular evaluation of a novel series of [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic esters and acids (II) as renal vasodilators is presented. The compound 3-[6,7-dihydroxy-4-methyl-(1H)-quinazoline-2-one-1-yl]propanoic acid (7) was found to be a potent and selective renal vasodilator.
