143700-04-3

Basic information

• Product Name: (R)-tert-butyl 3-azidopyrrolidine-1-carboxylate
• Synonyms: (R)-tert-butyl 3-azidopyrrolidine-1-carboxylate
• CAS NO: 143700-04-3
• Molecular Weight: 212.252
• Mol File: 143700-04-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 3-azidopyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 3-azidopyrrolidine-1-carboxylate(143700-04-3)
• EPA Substance Registry System: (R)-tert-butyl 3-azidopyrrolidine-1-carboxylate(143700-04-3)

Safety Data

• Hazardous Substances Data: 143700-04-3(Hazardous Substances Data)

Usage

General Description

(R)-tert-butyl 3-azidopyrrolidine-1-carboxylate is a chemical compound that belongs to the class of azidopyrrolidine carboxylates. It is a derivative of pyrrolidine, which has a five-membered ring containing one nitrogen atom. The tert-butyl group is attached to the nitrogen atom of the pyrrolidine ring, and there is an azide group (N3) attached to the third carbon atom of the ring. (R)-tert-butyl 3-azidopyrrolidine-1-carboxylate has been studied for its potential use in organic synthesis and as a building block in the preparation of various functionalized pyrrolidines. It is also known to have potential applications in medicinal chemistry as a precursor for the synthesis of bioactive molecules. Its properties and reactivity make it a valuable compound for researchers in organic and medicinal chemistry.

Upstream product

• 139986-03-1 1,1-dimethylethyl-3(R)-{[(4-methylphenyl)sulphonyl]oxy}-1-pyrrolidinecarboxylate 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 371240-55-0 (S)-3-(toluene-4-sulfonyloxy)pyrrolidin-1-ylcarboxylic acid tert-butyl ester 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 132945-75-6 (S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate 

Downstream Products

• 147081-49-0 (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

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Disclosed are heteroaryl derivatives, pharmaceutical composition and uses in the manufacture of a medicine for treating respiratory diseases, especially for chronic obstructive pulmonary disease (COPD).

4-Aminothiourea prolinol tert-butyldiphenylsilyl ether: A chiral secondary amine-thiourea as organocatalyst for enantioselective anti-mannich reactions

anti-Selective Mannich reactions of N-p-methoxyphenyl (PMP)-protected α-iminoglyoxylate with unmodified aldehydes or ketones were effectively catalyzed by 4-aminothiourea prolinol tert-butyldiphenylsilyl ether. The reactions led to chiral β-amino carbonyl compounds in high yields (up to 94%), excellent diastereo- and enantioselectivities (up to 98% de and >99% ee). The study demonstrated for the first time that direct Mannich-type reactions of unmodified aldehydes or ketones to aiminoglyoxylate can be promoted by secondary amine-thiourea chiral organocatalyst.

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