14371-82-5

Usage

Uses

Used in Organic Synthesis:
2-Nitro-4-(trifluoromethyl)thiophenol is used as a chemical intermediate for the synthesis of various organic compounds. Its unique chemical properties, including the presence of a nitro group and a trifluoromethyl group, make it a valuable building block in the creation of complex molecules. Although it does not have a very common application, its reactivity and stability contribute to its utility in the field of organic synthesis.

InChI:InChI=1/C7H4F3NO2S/c8-7(9,10)4-1-2-6(14)5(3-4)11(12)13/h1-3,14H

Upstream product

• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 860-39-9 bis(2-nitro-4-trifluoromethylphenyl) disulfide 

Downstream Products

• 19406-49-6 2-amino-4-trifluoromethylthiophenol 
• 71236-97-0 Methyl-2-nitro-4-trifluormethylphenylsulfoxid 
• 364-48-7 methyl-(2-nitro-4-trifluoromethyl-phenyl)-sulfone 
• 1338360-55-6 1-(butylsulfanyl)-2-nitro-4-(trifluoromethyl)benzene 
• 22057-35-8 1-(ethylsulfanyl)-2-nitro-4-(trifluoromethyl)benzene 
• 1338360-54-5 2-nitro-1-(propylsulfanyl)-4-(trifluoromethyl)benzene 
• 738-06-7 1-(benzylsulfanyl)-2-nitro-4-(trifluoromethyl)benzene 
• 1115577-86-0 C₂₄H₂₉ClF₃N₃O₂S 
• 1115576-91-4 2-{allyl[2-nitro-4-(trifluoromethyl)phenyl]amino}-N-cyclohexyl-4-methylpentanethioamide 
• 1115576-88-9 2-{(4-chlorobenzyl)[2-nitro-4-(trifluoromethyl)phenyl]amino}-N-cyclohexyl-4-methylpentanethioamide 
• 1115577-76-8 C₂₄H₂₇ClF₃N₃O₂S 
• 71236-96-9 1-(methylsulfanyl)-2-nitro-4-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

One-pot synthesis and asymmetric oxidation of 2-nitro-4-(trifluoromethyl) benzene containing sulfides

An efficient one-pot method for the preparation of 2-nitro-4- (trifluoromethyl)benzene containing sulfides from 1,1'-disulfanediylbis[2-nitro- 4-(trifluoromethyl)benzene] is proposed. The corresponding enantiomerically enriched sulfoxides with up to 78% enantiomeric excess are prepared by the asymmetric oxidation of sulfides using a modified Sharpless method. The yield of sulfoxides is shown to decrease with an increase in the bulk of the aliphatic group and with a decrease of the inductive effect of the hydrocarbonic moiety on the sulfur atom. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Taylor & Francis Group, LLC.

THE SYNTHESIS OF o-NITROBENZENETHIOLS: AN ADVANTAGEOUS NUCLEOPHILIC DISPLACEMENT ON o-CHLORONITROBENZENES

Reaction of substituted o-chloronitrobenzenes with sodium sulphide in DMSO occurs rapidly and gives the corresponding o-nitrobenzenethiols, following a convenient one-step pathway.Better yields are obtained when stoicheiometric amounts of sulphur, dissolved in a little carbon disulphide, are added in the presence of ethyl methyl ketone as solvent.