14372-55-5Relevant academic research and scientific papers
A new application for diethyl azodicarboxylate: Efficient and regioselective thiocyanation of aromatics amines
Iranpoor, Nasser,Firouzabadi, Habib,Khalili, Dariush,Shahin, Rezvan
, p. 3508 - 3510 (2010)
Highly regioselective thiocyanations of indoles, anilines and pyrrole are achieved via an efficient and simple protocol using NH4SCN and diethyl azodicarboxylate (DEAD) as a mild oxidant.
Design, synthesis, characterization and biological evaluation of 6- methoxy-2-aminobenzothioate derivatives against certain bacterial strains
Juber, Ahmood K.,Hamed, Ahmed Solaiman,Khalil, Ahmed Moussa
, p. 4131 - 4139 (2020/11/18)
The current work reports the synthesized and biological evaluation of 6-methoxy-2-amino benzothiazole (A1), which was prepared via reaction p-Ansidine with ammonium thiocyanate followed by the oxidative ring closure of the resultant thiourea with a catalytic amount of bromine, in the alkaline medium. The resulting compound(A1) underwent condensation reactions with various kinds of aldehydes to produce Hydrazones (A3ad). 6-methoxy2-hydrazinobenzothiazole (A2) was prepared through the reaction of the compound (A1) with 99.9 % hydrazine hydrate in the presence of concentrated HCl and ethylene glycol solution. After that, the compound (A2) was reacted with ethyl acetoacetate in alcohol to yield corresponding pyrazole-6- methoxybenzothiazole (A4). Moreover, the compound (A2) was reacted with 4- substituted aromatic aldehydes in absolute ethanol to create Hydrazones (A5a-d). Synthesized compounds were investigated as anti-bacterial activity against five microorganisms: (Gram-positive: Bacillus subtilis & Staphylococcus aurea). (Gramnegative: Pseudomonas aeruginous Escherichia coli and Enterobacter)
Graphene oxide: A promising carbocatalyst for the regioselective thiocyanation of aromatic amines, phenols, anisols and enolizable ketones by hydrogen peroxide/KSCN in water
Khalili, Dariush
, p. 2547 - 2553 (2016/03/19)
Graphene oxide (GO), as a heterogeneous carbocatalyst, catalyzes the direct thiocyanation of a variety of arenes including aromatic amines, phenols, anisols and carbonyl compounds that possessing α-hydrogen in the presence of hydrogen peroxide and KSCN in water as a green media. This procedure is chemoselective, avoids the use of precious metals and toxic solvents and has a broad substrate scope. Easy removal from the reaction mixture and recyclability with no loss of activity are the key features of graphene oxide in this catalytic system.
