143724-69-0

Basic information

• Product Name: Kaempferol 3,4',7-triacetate
• Synonyms: Kaempferol 3,4',7-triacetate;2-(4-Acetoxyphenyl)-5-hydroxy-4-oxo-4H-chromene-3,7-diyl diacetate
• CAS NO: 143724-69-0
• Molecular Formula: C₂₁H₁₆O₉
• Molecular Weight: 412
• Mol File: 143724-69-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Kaempferol 3,4',7-triacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Kaempferol 3,4',7-triacetate(143724-69-0)
• EPA Substance Registry System: Kaempferol 3,4',7-triacetate(143724-69-0)

Safety Data

• Hazardous Substances Data: 143724-69-0(Hazardous Substances Data)

Usage

General Description

Kaempferol 3,4',7-triacetate is a chemical compound derived from the naturally occurring flavonoid, kaempferol. It is a derivative of kaempferol that has three acetyl groups attached to its structure, at the 3, 4', and 7 positions. This modification alters the chemical properties of kaempferol and may affect its biological activity. Kaempferol itself is known for its antioxidant and anti-inflammatory properties, and it is found in various fruits and vegetables. Kaempferol 3,4',7-triacetate may have similar or different biological effects compared to kaempferol, and its potential applications in pharmaceuticals or dietary supplements are currently being investigated.

Upstream product

• 520-18-3 kaempferol 
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Relevant articles and documents

Polymethoxyflavones from Gardenia oudiepe (Rubiaceae) induce cytoskeleton disruption-mediated apoptosis and sensitize BRAF-mutated melanoma cells to chemotherapy

A series of 10 natural and semisynthetic flavonoids (1 to 10) were obtained from Gardenia oudiepe (Rubiaceae), an endemic plant from New Caledonia. Most of them were polymethoxylated flavones (PMFs) of rare occurrence. After a cell viability screening test, PMFs 2 and 3 showed significant cytotoxic activity against A2058 human melanoma cells (IC50 = 3.92 and 8.18 μM, respectively) and were selected for in-depth pharmacological assays. Both compounds inhibited cell migration and induced apoptosis and cell cycle arrest after 72h of treatment. Immunofluorescence assays indicated that these outcomes were possibly related to the induction of cytoskeleton disruption associated to actin and tubulin depolymerization. These data were confirmed by molecular docking studies, which showed a good interaction between PMFs 2 and 3 and tubulin, particularly at the colchicine binding site. As A2058 are considered as chemoresistant to conventional chemotherapy, compounds 2 and 3 (?IC50) were associated to clinically-used antimelanoma drugs (vemurafenib and dacarbazine) and combined therapies efficacy was assessed by the MTT assay. PMFs 2 restored the sensitivity of A2058 cells to dacarbazine treatment (IC50 = 49.38 μM vs. >100 μM). Taken together, these data suggest that PMFs from G. oudiepe could be potential leaders for the design of new antimelanoma drugs.

Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae)

A series of 16 flavonoids were isolated and prepared from bud exudate of Gardenia urvillei and Gardenia oudiepe, endemic to New Caledonia. Most of them are rare polymethoxylated flavones. Some of these compounds showed noticeable activity against Leishmania (Leishmania) amazonensis, Plasmodium falciparum and Trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. We also provide a full set of NMR data as some of the flavones were incompletely described.