1437304-87-4Relevant articles and documents
A [...] urea and its preparation and use
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Paragraph 0050-0052, (2017/04/22)
The invention discloses quinazoline arylurea compounds and a preparation method and an application thereof, wherein the quinazoline arylurea compounds have a general formula I. The new compound with quinazolinyl and aryl-substituted urea shows extremely high activity in suppressing the growth of tumor cells, and particularly realizes an obvious effect in suppressing the growth of VEGFR high-expression HUVEC cells, wherein half of the suppression IC50 values can reach 1.8 mu g/mL. The invention also provides a preparation method of the compounds.