1437308-16-1

Basic information

• Product Name: (2R,4S)-dimethyl 5-iodo-4-((3-iodo-5-methoxyphenyl)amino)-7-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate
• Synonyms: (2R,4S)-dimethyl 5-iodo-4-((3-iodo-5-methoxyphenyl)amino)-7-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate
• CAS NO: 1437308-16-1
• Molecular Weight: 666.251
• Mol File: 1437308-16-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4S)-dimethyl 5-iodo-4-((3-iodo-5-methoxyphenyl)amino)-7-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-dimethyl 5-iodo-4-((3-iodo-5-methoxyphenyl)amino)-7-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate(1437308-16-1)
• EPA Substance Registry System: (2R,4S)-dimethyl 5-iodo-4-((3-iodo-5-methoxyphenyl)amino)-7-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate(1437308-16-1)

Safety Data

• Hazardous Substances Data: 1437308-16-1(Hazardous Substances Data)

Upstream product

• 600-22-6 pyruvic acid methyl ester 
• 62605-98-5 1-iodo-5-methoxy-phenylamine 

Relevant articles and documents

A highly diastereo- and enantioselective synthesis of tetrahydroquinolines: Quaternary stereogenic center inversion and functionalization

Tetrahydroquinolines containing two quaternary stereogenic centers were synthesized with excellent ee and dr via a four-component cyclization reaction catalyzed by a chiral phosphoric acid. High chemoselectivity was achieved by differentiating anilines with similar reactivities to yield diverse hybrid products. The chirality of the quaternary C4 atom of the 4-aminotetrahydroquinoline products was found to undergo highly stereoselective inversion, enabling facile functionalization using a wide range of nucleophiles (C, O, N, and S).