62605-98-5

Basic information

• Product Name: 3-IODO-5-METHOXYANILINE
• Synonyms: 3-IODO-5-METHOXYANILINE;3-iodo-5-methoxybenzenamine;3-Iodo-5-methoxyphenylamine
• CAS NO: 62605-98-5
• Molecular Formula: C₇H₈INO
• Molecular Weight: 249.046
• Mol File: 62605-98-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 337.654 °C at 760 mmHg
• Flash Point: 158.008 °C
• Appearance: /
• Density: 1.807 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 3-IODO-5-METHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-5-METHOXYANILINE(62605-98-5)
• EPA Substance Registry System: 3-IODO-5-METHOXYANILINE(62605-98-5)

Safety Data

• Hazardous Substances Data: 62605-98-5(Hazardous Substances Data)

Usage

General Description

3-IODO-5-METHOXYANILINE is a chemical compound with the molecular formula C7H8INO and a molecular weight of 239.05 g/mol. It is a white to off-white crystalline solid that is sparingly soluble in water. 3-IODO-5-METHOXYANILINE is primarily used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also utilized in the manufacture of pesticides, fungicides, and other agricultural chemicals. 3-IODO-5-METHOXYANILINE is a substance that requires careful handling and storage due to its potential health hazards and reactivity with other chemicals.

InChI:InChI=1/C7H8INO/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,9H2,1H3

Upstream product

• 99-65-0 meta-dinitrobenzene 
• 98-95-3 nitrobenzene 
• 586-10-7 3-methoxy-5-nitroaniline 
• 5327-44-6 3,5-dinitroanisole 
• 79990-25-3 1-iodo-3-methoxy-5-nitro-benzene 
• 6276-04-6 3,5-dinitroiodobenzene 

Downstream Products

• 1352622-34-4 C₁₆H₁₀ClN₃O 
• 1333950-16-5 C₂₃H₁₆ClN₅O 
• 1333950-30-3 C₂₂H₁₅ClN₆O 
• 1333950-32-5 C₉H₆ClNO 
• 861800-86-4 1-chloro-3-iodo-5-methoxybenzene 
• 1437308-16-1 (2R,4S)-dimethyl 5-iodo-4-((3-iodo-5-methoxyphenyl)amino)-7-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate 
• 1251863-64-5 C₁₇H₂₄BF₃N₂O₄ 
• 1251863-63-4 C₁₁H₁₂F₃IN₂O₂ 
• 1251863-62-3 C₉H₈F₃IN₂O₂ 
• 1251863-07-6 1-{3-Ethoxy-5-[7-(5-methyl-[1,3,4]oxadiazol-2-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea 
• 269411-75-8 3-benzyloxy-5-iodo-benzamide 
• 269411-51-0 3-(3-carbamoyl-5-hydroxy-phenyl)-acrylic acid ethyl ester 
• 269411-74-7 3-hydroxy-5-iodo-benzamide 
• 269411-73-6 3-iodo-5-methoxy-benzamide 

Relevant articles and documents

Synthesis, Biological Evaluation, and Computational Analysis of Biaryl Side-Chain Analogs of Solithromycin

There is an urgent need for new antibiotics to mitigate the existential threat posed by antibiotic resistance. Within the ketolide class, solithromycin has emerged as one of the most promising candidates for further development. Crystallographic studies of bacterial ribosomes and ribosomal subunits complexed with solithromycin have shed light on the nature of molecular interactions (π-stacking and H-bonding) between from the biaryl side-chain of the drug and key residues in the 50S ribosomal subunit. We have designed and synthesized a library of solithromycin analogs to study their structure-activity relationships (SAR) in tandem with new computational studies. The biological activity of each analog was evaluated in terms of ribosomal affinity (Kd determined by fluorescence polarization), as well as minimum inhibitory concentration assays (MICs). Density functional theory (DFT) studies of a simple binding site model identify key H-bonding interactions that modulate the potency of solithromycin analogs.

Substituted benzamide inhibitors of rhinovirus 3C protease

Nonpeptide benzamide-containing inhibitors of human rhinovirus (HRV) 3C protease are described.