143760-30-9

Upstream product

• 5631-35-6 1-[4,4-bis(4-fluorophenyl)butyl]piperazine 
• 42592-04-1 N-(2,3-epoxypropyl)-N-ethoxycarbonylaniline 
• 101-99-5 N-carboethoxyaniline 

Downstream Products

• 143759-63-1 1-[4,4-bis(4-fluorophenyl)butyl]-4-(2-hydroxy-3-phenylaminopropyl)-piperazine 

Relevant academic research and scientific papers

Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter

A new series of diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter (DAT), which were modified at both the diphenylalkyl moiety and the phenyl ring in the phenylamino moiety of 1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine 1, was evaluated for their inhibitory activities against auto-oxidative lipid peroxidation in canine brain homogenates. Some of these were approximately equivalent in activity to α-tocopherol as a potent antioxidant with IC50 values of low micromolar order, and the 4-hydroxyphenyl derivative 11 showed the most potent antioxidative activity with an IC 50 value of 0.32μM, exhibiting approximately 5-fold more potent activity than α-tocopherol. The structure-activity relationship (SAR) studies of the antioxidative activity of these derivatives are presented.

Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system

A new series of diphenyl piperazine derivatives containing the phenyl substituted aminopropanol moiety, which were modified at sites between the diphenyl and piperazine moieties, was prepared and evaluated for dopamine transporter binding affinity with [

Diphenylpiperazine derivative and drug for circulatory organ containing the same

A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: STR1 wherein R1 and R2 may be the same or different from each other a