143774-34-9

Upstream product

• 53915-69-8 allenyltributylstannane 
• 144072-30-0 4-((tert-butoxycarbonyl)amino)benzaldehyde 
• 144072-29-7 tert-butyl N-[4-(hydroxymethyl)phenyl]carbamate 
• 623-04-1 4-aminobenzenemethanol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 144072-39-9 diethyl 2-<1-<4-phenyl>-3-butynyl>malonate 
• 144072-40-2 ethyl 3-<4-phenyl>-5-hexynoate 
• 144072-34-4 3-<4-phenyl>-5-hexynoic acid 
• 149577-66-2 4-(4-guanidinophenyl)-6-(E)-(iodomethylidene)tetrahydro-2-pyranone 
• 144072-36-6 3-(4-guanidinophenyl)-5-hexynoic acid 
• 149577-65-1 4-(4-guanidinophenyl)-6-methylidenetetrahydro-2-pyranone 
• 144072-35-5 3-(4-aminophenyl)-5-hexynoic acid 
• 144072-38-8 [4-(1-Chloro-but-3-ynyl)-phenyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Guanidinophenyl-Substituted Enol Lactones as Selective, Mechanism-Based Inhibitors of Trypsin-like Serine Proteases

We have synthesized four guanidinophenyl-substituted protio enol and iodo enol lactones (3-(4-guanidinophenyl)-6-methylidenetetrahydro-2-pyranone (1), 3-(4-guanidinophenyl)-6-(E)-(iodomethylidene)tetrahydro-2-pyranone (2), 4-(4-guanidinophenyl)-6-methylidenetetrahydro-2-pyranone (3), and 4-(4-guanidinophenyl)-6-(E)-(iodomethylidene)tetrahydro-2-pyranone (4)) and tested them for inhibitory activity against some trypsin-like enzymes, namely trypsin, urokinase, tissue plasminogen activator (t-PA), plasmin, and thrombin, as well as α-chymotrypsin and human neutrophil elastase (HNE).The β-aryl-substituted protio lactone 3 was a potent alternate substrate inhibitor of trypsin and urokinase.The α-aryl-substituted iodo lactone 2 was a permanent inactivator of urokinase, plasmin, t-PA, thrombin, and α-chymotrypsin, exhibiting a relatively high specificity for the former two enzymes.In general, these compounds showed a preference for inactivating trypsin-like enzymes over α-chymotrypsin and HNE.Also, within the class of trypsin-like enzymes, there was generally good selectivity of inhibition.