1437776-63-0

Basic information

• Product Name: 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxylmethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethoxyl}phenyl)ethanone
• Synonyms: 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxylmethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethoxyl}phenyl)ethanone
• CAS NO: 1437776-63-0
• Molecular Weight: 482.598
• Mol File: 1437776-63-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxylmethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethoxyl}phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxylmethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethoxyl}phenyl)ethanone(1437776-63-0)
• EPA Substance Registry System: 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxylmethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethoxyl}phenyl)ethanone(1437776-63-0)

Safety Data

• Hazardous Substances Data: 1437776-63-0(Hazardous Substances Data)

Upstream product

• 1192063-72-1 racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate 
• 1437778-81-8 2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethanol 
• 1416366-34-1 2-chloro-5-(methoxymethyl)pyrimidine 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 1046816-75-4 2-chloro-5-hydroxymethyl-pyrimidine 
• 1402554-67-9 benzyl 4-[(1R,2S)-2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate 
• 1192063-81-2 tert-butyl 4-[(1Z,4R)-5-(benzyloxy)-4-hydroxypent-1-en-1-yl]piperidine-1-carboxylate 
• 1192063-78-7 tert-butyl 4-[(4R)-5-(benzyloxy)-4-hydroxypent-1-yn-1-yl]piperidine-1-carboxylate 
• 503-29-7 azetidine 
• 1437778-94-3 {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid 
• 287192-97-6 4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1437778-93-2 methyl {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetate 
• 91361-59-0 methyl 2-(2-fluoro-4-hydroxyphenyl)acetate 
• 68886-07-7 (2-fluoro-4-hydroxylphenyl)acetic acid 

Relevant articles and documents

Discovery of phenyl acetamides as potent and selective GPR119 agonists

The paper describes the SAR/SPR studies that led to the discovery of phenoxy cyclopropyl phenyl acetamide derivatives as potent and selective GPR119 agonists. Based on a cis cyclopropane scaffold discovered previously, phenyl acetamides such as compound 17 were found to have excellent GPR119 potency and improved physicochemical properties. Pharmacokinetic data of compound 17 in rat, dog and rhesus will be described. Compound 17 was suitable for QD dosing based on its predicted human half-life, and its projected human dose was much lower than that of the recently reported structurally-related benzyloxy compound 2. Compound 17 was selected as a tool compound candidate for NHP (Non-Human Primate) efficacy studies.