1437778-94-3

Basic information

• Product Name: {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid
• Synonyms: {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid
• CAS NO: 1437778-94-3
• Molecular Weight: 443.518
• Mol File: 1437778-94-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid(1437778-94-3)
• EPA Substance Registry System: {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid(1437778-94-3)

Safety Data

• Hazardous Substances Data: 1437778-94-3(Hazardous Substances Data)

Upstream product

• 68886-07-7 (2-fluoro-4-hydroxylphenyl)acetic acid 
• 1266335-37-8 tert-butyl 4-[(1R,2S)-2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate 
• 1192063-72-1 racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate 
• 1437778-81-8 2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethanol 
• 1416366-34-1 2-chloro-5-(methoxymethyl)pyrimidine 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 1046816-75-4 2-chloro-5-hydroxymethyl-pyrimidine 
• 1402554-67-9 benzyl 4-[(1R,2S)-2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate 
• 1192063-81-2 tert-butyl 4-[(1Z,4R)-5-(benzyloxy)-4-hydroxypent-1-en-1-yl]piperidine-1-carboxylate 
• 1192063-78-7 tert-butyl 4-[(4R)-5-(benzyloxy)-4-hydroxypent-1-yn-1-yl]piperidine-1-carboxylate 
• 287192-97-6 4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1437778-93-2 methyl {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetate 
• 91361-59-0 methyl 2-(2-fluoro-4-hydroxyphenyl)acetate 

Downstream Products

• 1437779-20-8 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide 
• 1437778-75-0 2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine 
• 1437776-63-0 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxylmethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethoxyl}phenyl)ethanone 

Relevant articles and documents

GPR119 AGONISTS

This disclosure is directed, at least in part, to GPR119 agonists useful for the treatment of conditions or disorders involving the gut-brain axis. In some embodiments, the GPR119 agonists are gut-restricted compounds. In some embodiments, the condition or disorder is a metabolic disorder, such as diabetes, obesity, nonalcoholic steatohepatitis (NASH), or a nutritional disorder such as short bowel syndrome.

SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS

Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included