1437798-34-9

Upstream product

• 1437798-61-2 4-benzyl-3-phenyl-5-(m-tolyl)-4,5-dihydro-1,2,4-oxadiazole 
• 698-16-8 benzohydroximoyl chloride 
• 3488-55-9 N-hydroxy-N'-(phenylmethyl)-benzenecarboximidamide 
• 100-46-9 benzylamine 
• 1508262-91-6 N-benzyl-N'-(pivaloyloxy)benzimidamide 
• 1508262-44-9 N-benzyl-2-methyl-N-(phenyl((pivaloyloxy)imino)methyl)benzamide 
• 120-46-7 1,3-diphenylpropanedione 
• 52107-93-4 2-iodo-3-methylbenzoyl chloride 
• 108078-14-4 2-iodo-3-methylbenzoic acid 
• 1256846-61-3 2-iodo-N-benzyl-3-methylbenzamide 
• 98815-39-5 (Z)-3-amino-1,3-diphenylprop-2-en-1-one 

Relevant academic research and scientific papers

Syntheses of quinazolinones from 2-iodobenzamides and enaminones via copper-catalyzed domino reactions

N-Substituted 2-iodobenzamides and enaminones undergo cascade transformations to achieve quinazolinones via a copper-catalyzed Ullmann-type coupling, a Michael addition and a retro-Mannich reaction. A unique stereochemical feature of this domino process was that Z-enaminones reacted without external ligands, whereas E-enaminones required the assistance of ligands. This journal is

Copper-catalyzed redox-neutral C-H amination with amidoximes

CuI-catalyzed reactions of N-alkylamidoximes afforded dihydroimidazoles via sp3 C-H amination. On the other hand, the reactions of N-benzoylamidoximes resulted in sp2 C-H amination to form quinazolinones. The reaction mechanisms could be characterized as a redox-neutral radical pathway including a Cu(i)-Cu(ii) redox catalytic cycle. The Royal Society of Chemistry.

Oxidative radical skeletal rearrangement induced by molecular oxygen: Synthesis of quinazolinones

Oxidative skeletal rearrangement of 5-aryl-4,5-dihydro-1,2,4-oxadiazoles into quinazolinones is induced by molecular oxygen (under a dry air atmosphere) that likely proceeds via transient iminyl radical species. Concise syntheses of biologically active qu