98815-39-5

Basic information

• Product Name: 2-Propen-1-one, 3-amino-1,3-diphenyl-, (2Z)-
• Synonyms: 2-Propen-1-one,3-amino-1,3-diphenyl-,(2Z);3-amino-1,3-diphenyl-2-propenone
• CAS NO: 98815-39-5
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Mol File: 98815-39-5.mol
• Article Data: 41

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-amino-1,3-diphenyl-, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-amino-1,3-diphenyl-, (2Z)-(98815-39-5)
• EPA Substance Registry System: 2-Propen-1-one, 3-amino-1,3-diphenyl-, (2Z)-(98815-39-5)

Safety Data

• Hazardous Substances Data: 98815-39-5(Hazardous Substances Data)

Upstream product

• 4894-23-9 3,5-diphenyl-4,5-dihydro-isoxazole 
• 2039-49-8 3,5-diphehylisoxazole 
• 698-16-8 benzohydroximoyl chloride 
• 536-74-3 phenylacetylene 
• 98-86-2 acetophenone 
• 93-58-3 benzoic acid methyl ester 
• 77287-34-4 formamide 
• 120-46-7 1,3-diphenylpropanedione 
• 10403-54-0 phenyl (3-phenyl-2H-aziren-2-yl)methanone 
• 947590-32-1 3-azido-1,3-diphenylpropan-1-one 
• 65731-18-2 (Z)-N-(3-oxo-1,3-diphenylprop-1-en-1-yl)acetamide 
• 57957-24-1 N-(1-phenylvinyl)acetamide 
• 16717-64-9 1-azidostyrene 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 16232-42-1 2-oxo-4,6-diphenyl-1,2-dihydropyridine-3-carbonitrile 
• 170238-81-0 2,2,3,3,4,4,4-Heptafluoro-N-((Z)-3-oxo-1,3-diphenyl-propenyl)-butyramide 
• 120-46-7 1,3-diphenylpropanedione 
• 77989-16-3 3-benzoyl-4-phenyl-1,2,5-thiadiazole 
• 1145-01-3 3,5-Diphenylpyrazole 
• 19311-79-6 1-methyl-3,5-diphenyl-1H-pyrazole 
• 2183-27-9 1,3,5-triphenyl-1H-pyrazole 
• 3298-23-5 3,4,6-triphenylpyridin-2(1H)-one 
• 1547432-61-0 (Z)-N-(3-oxo-1,3-diphenylprop-1-enyl)-2-phenylacetamide 
• 1547432-63-2 (Z)-N-(3-oxo-1,3-diphenylprop-1-en-1-yl)propionamide 
• 13220-01-4 (2,5-diphenyl-1H-pyrrol-3-yl)(phenyl)methanone 

Relevant articles and documents

Metal-Free Cascade Annulation Approach for Modular Assembly of Alkynyl/Benzoyl Functionalized Quinolines

A concise and efficient synthetic method for alkynyl quinolines through TfOH-promoted cascade 1,4-conjugate addition/intramolecular annulation/aromatization process is established. By virtue of reactive aza-o-AQM (in situ generated from modular propargylamine), this reaction proceeds smoothly to afford a variety of alkynyl quinolines in good to excellent yields. This transition-metal-free process features halogen groups tolerance, such as the ?Cl, ?Br, and ?I groups; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of halogenated quinolines.

Iodine-Promoted Formal [3+2] Cycloaddition of Enaminone: Access to 2-Hydroxy-1,2-dihydro-pyrrol-3-ones with Quaternary Carbon Center

A novel iodine promoted cyclization of enaminone with aryl methyl ketones has been developed as a straightforward method for constructing 2-hydroxy-pyrrol-3(2H)-ones. This strategy affords structurally diverse 2-hydroxy-pyrrol-3(2H)-ones rings in high yields. Moreover, a quarternary alcohol has been constructed efficiently in the reaction. Product purification required only washing with CH2Cl2 solvent, thereby avoiding traditional chromatography and recrystallization, making this an example of group-assisted purification chemistry.

Unusual Reactivity of 4-Vinyl Isoxazoles in the Copper-Mediated Synthesis of Pyridines, Employing DMSO as a One-Carbon Surrogate

An efficient protocol for the synthesis of nicotinate derivatives and tetrasubstituted pyridines through a copper-mediated cleavage of isoxazoles has been developed. The highlight of the work is the observation of an unusual reactivity of 4-vinyl isoxazoles under the reaction conditions. DMSO serves as a one-carbon surrogate generating an active methylene group during the reaction to form two C-C bonds. This protocol provides a facile and an expeditious approach for the assembly of densely substituted N-heterocyclic compounds.