1437799-07-9Relevant academic research and scientific papers
Ugi four-component reaction of alcohols: Stoichiometric and catalytic oxidation/MCR sequences
Drouet, Fleur,Masson, Géraldine,Zhu, Jieping
, p. 2854 - 2857 (2013/07/26)
A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1-2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of primary alcohols were oxidized to the aldehyde that were directly engaged in the Ugi four-component reaction to afford α-acetamidoamides in good to excellent yields.
