14379-28-3

Basic information

• Product Name: N-Dodecanoyl-L-valine
• Synonyms: N-DODECANOYL-VALINE;N-DODECANOYL-L-VALINE
• CAS NO: 14379-28-3
• Molecular Formula: C17H33NO3
• Molecular Weight: 299.45
• Mol File: 14379-28-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 470.2 °C at 760 mmHg
• Flash Point: 238.2 °C
• Appearance: /
• Density: 0.964 g/cm³
• Vapor Pressure: 3.85E-10mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: N-Dodecanoyl-L-valine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Dodecanoyl-L-valine(14379-28-3)
• EPA Substance Registry System: N-Dodecanoyl-L-valine(14379-28-3)

Safety Data

• Hazardous Substances Data: 14379-28-3(Hazardous Substances Data)

Usage

General Description

N-Dodecanoyl-L-valine is a synthetic chemical compound classified as an ester and is primarily utilized in the systemic process and production of pharmaceutical drugs and antibiotics with varying medicinal benefits. It features a molecular structure containing carbon, hydrogen, oxygen, and nitrogen atoms. It is characterized by its high biodegradability, low toxicity, and its capacity to function as a surfactant. Its chemical name is derived from its components - dodecanoic acid and the amino acid, valine. It is soluble in organic solvents but has poor water solubility.

InChI:InChI=1/C17H33NO3/c1-4-5-6-7-8-9-10-11-12-13-15(19)18-16(14(2)3)17(20)21/h14,16H,4-13H2,1-3H3,(H,18,19)(H,20,21)/t16-/m0/s1

Upstream product

• 143-07-7 lauric acid 
• 72-18-4 L-valine 
• 60654-17-3 N-n-dodecanoyl methyl (L)-valinate 
• 112-16-3 n-dodecanoyl chloride 
• 6306-52-1 L-valine methylester hydrochloride 
• 14565-47-0 N-succinimidyl laurate 

Relevant articles and documents

Optical Resolution of Enantiomers with Chiral Mixed Micelles by Electrokinetic Chromatography

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A systematic understanding of gelation self-assembly: solvophobically assisted supramolecular gelation via conformational reorientation across amide functionality on a hydrophobically modulated dipeptide based ambidextrous gelator, N-n-acyl-(l)Val-X(OBn), (X = 1,ω-amino acid)

A systematic investigation on gelation self-assembly has been performed on a hydrophobically modulated dipeptide based ambidextrous gelator, N-n-acyl-(l)Val-X(OBn), (X = 1,ω-amino acid). To elucidate the effect of hydrophobic tuning on gelator architecture towards its gelation self-assembly, three sets of gelators with a common formula: CmH2m+1C(=O)NH(l)Val(C=O)NH-(CH2)n-(C=O)OBn, were synthesized, Set-I includes gelators with n = 2, m = 9, 11, 13, 15, 17, for Set-II it is n = 2, 3, 5, m = 13 and Set-III comprises of two isomeric gelators (n = 2, m = 15; n = 10, m = 7). Gelation has been critically analyzed in various apolar (aromatic and aliphatic) and polar (protic and aprotic) solvents using FESEM, CD, IR, WAXRD and rheological studies. Obtained results reveal that π-π type interaction dictates the primary molecular alignment and positioning of amide functionality across the aliphatic chain which influences the peptidic orientation in parallel (when m > n) or antiparallel (when m gel and yield stress of gel systems increases with m, but for a given m, the trend goes apparently inverse with the increasing n. Circular dichroism (CD) studies suggest an intriguing evidence of non-planarity of amide plane during self-assembly, highlighting the involvement of conformational change taking place during molecular organization towards its gelation. Despite complex nature of solvent-gelator interaction, the effect of H-bonding component of solubility parameters was found to have a significant role on self-assembly. Overall, supramolecular forces acting at specific functionalities encrypted in gelator backbone must overcome the solvation energy with synergic assistance of solvophobic effect towards stabilization of gel-network with optimum gelator backbone conformation for achieving required enthalpic contribution for self-assembly.

PPAR ACTIVITY REGULATORS

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