1438-13-7Relevant academic research and scientific papers
Screening method for the evaluation of asymmetric catalysts for the reduction of aliphatic ketones
Boukachabia, Mourad,Zeror, Saoussen,Collin, Jacqueline,Fiaud, Jean-Claude,Zouioueche, Louisa Aribi
, p. 1485 - 1489 (2011)
ATH reductions of aliphatic ketones in water catalyzed by ruthenium coordinated by prolinamide ligands produce alcohols with moderate enantiomeric excesses in most cases. A set of seven aliphatic ketones is proposed for a rapid evaluation of the enantioselectivity of catalysts by one-pot multi-substrates reduction. The screening of a library of prolinamides shows that according to the structure of the ketones different ligands give the best asymmetric inductions.
Male oral contraceptive N-alkylimidazole derivatives, compositions, and method of use therefor
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, (2008/06/13)
A compound useful as antifungal, antibacterial and antiprotozoal agents and as spermicides have the formula STR1 and the acid addition salts thereof wherein Z is oxygen or sulfur; m is 0, 1, 2 or 3; n is 1, 2 or 3; R1 is hydrogen; alkyl; cycloalkyl; cycloalkyl-lower-alkyl; optionally substituted phenyl; phenyl-lower-alkyl; monocyclic heteroaromatic ring; monocyclic heteroaromatic-lower-alkyl; naphthyl; or naphthyl-lower-alkyl. A and B are independently hydrogen, halo, lower alkyl or lower alkoxy and either one of A or B may be nitro, amino or alkanoylamino; Q is (a) NR2 R3 or (b) NR4 C(X)YR5 wherein X is oxygen or sulfur; Y is oxygen, sulfur, NR6 or a bond; R2 is hydrogen; alkyl; cycloalkyl; cycloalkyl-lower-alkyl; optionally substituted phenyl or optionally substituted phenyl-lower-alkyl; R3 is hydrogen or lower alkyl; or R2 and R3 together with N is a five or six membered optionally substituted ring; R4 and R6 are independently hydrogen or lower alkyl; R5 is lower alkyl; cycloalkyl; phenyl; or optionally substituted phenyl or phenyl-lower-alkyl.
