2245-30-9

Basic information

• Product Name: 3,3-DIMETHYL-1,2-EPOXYBUTANE
• Synonyms: 1,1-Dimethylethyl-oxirane;2-tert-Butyloxirane;3,3-Dimethylbutene oxide;Butane, 1,2-epoxy-3,3-dimethyl-;Oxirane, (1,1-dimethylethyl)-;Oxirane, 2-(1,1-dimethylethyl)-;tert-Butylethylene oxide;tert-Butyloxirane
• CAS NO: 2245-30-9
• Molecular Formula: C₆H₁₂O
• Molecular Weight: 100.16
• EINECS: 218-831-4
• Mol File: 2245-30-9.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 95-96°C
• Flash Point: -1°C
• Appearance: /
• Density: 0,822 g/cm3
• Vapor Pressure: 62mmHg at 25°C
• Refractive Index: 1.4010
• BRN: 102478
• CAS DataBase Reference: 3,3-DIMETHYL-1,2-EPOXYBUTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DIMETHYL-1,2-EPOXYBUTANE(2245-30-9)
• EPA Substance Registry System: 3,3-DIMETHYL-1,2-EPOXYBUTANE(2245-30-9)

Safety Data

• Hazard Codes: Xn
• Statements: 11-36/37/38-22
• Safety Statements: 16-23-33-36
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 2245-30-9(Hazardous Substances Data)

Usage

Uses

3,3-Dimethyl-1,2-epoxybutane is used as pharm and intermediates.

InChI:InChI=1/C6H12O/c1-6(2,3)5-4-7-5/h5H,4H2,1-3H3/t5-/m0/s1

Upstream product

• 1438-13-7 3,3-dimethyl-1-bromo-2-butanol 
• 13547-70-1 1-chloro-3,3-dimethyl-butan-2-one 
• 5469-26-1 1-Bromopinacolon 
• 31612-63-2 (R)-3,3-dimethylbutane-1,2-diol 
• 558-37-2 tert-butylethylene 
• 2245-30-9 1,2-epoxy-3,3-dimethylbutane 
• 32659-48-6 (S)-2-chloro-3,3-dimethylbutanoic acid 
• 20859-02-3 L-tert-Leucine 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 139040-45-2 (R)-1,1,1-trichloromethyl-3,3-dimethyl-2-butanol 
• 36965-30-7 3,3-dimethyl-1,1,1-trichloro-2-butanone 
• 152611-54-6 Chloro-acetic acid (R)-1-chloromethyl-2,2-dimethyl-propyl ester 
• 152488-35-2 Chloro-acetic acid 1-chloromethyl-2,2-dimethyl-propyl ester 
• 36402-31-0 3,3-dimethyl-1-chloro-2-butanol 

Downstream Products

• 144788-75-0 (1S,3S)-1-[((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-dimethyl-silanyl]-4,4-dimethyl-1-phenyl-pentan-3-ol 
• 144712-78-7 (1S,3R)-1-[((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-dimethyl-silanyl]-4,4-dimethyl-1-phenyl-pentan-3-ol 
• 130748-11-7 1-[(2-Hydroxy-3,3-dimethyl-butyl)-phenyl-phosphanyl]-3,3-dimethyl-butan-2-ol 
• 123271-33-0 diphenyl (2-hydroxy-3,3-dimethylbutyl)phosphine 
• 2245-30-9 (R)-tert-butyloxirane 
• 40102-55-4 (S)-(-)-3,3-dimethyl-1,2-epoxybutane 
• 31612-63-2 (R)-3,3-dimethylbutane-1,2-diol 
• 31612-63-2 (2S)-3,3-dimethylbutane-1,2-diol 
• 2050-03-5 4-tert-pentylanisole 
• 348135-18-2 1-((2,6-dimethylphenyl)amino)-3,3-dimethylbutan-2-ol 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 118102-24-2 ((C₆H₅)C(C₄H₂N))4AlOC(C(CH₃)3)CH(CH₂)2CH₃ 
• 1038436-25-7 (R)-(-)-1-[2-(benzyloxy)-5-methoxyphenoxy]-3,3-dimethylbutan-2-ol 
• 1038436-37-1 (R)-(-)-1-[2-(benzyloxy)-5-bromophenoxy]-3,3-dimethylbutan-2-ol 

Relevant articles and documents

A Facile Enzyme Assisted Route to (R)- and (S)-t-Butyloxirane and related β-Amino Alcohols - Catalysts for the Enantioselective Addition of Dialkylzinc Reagents to Aldehydes

(R) and (S)-t-butyloxirane have been prepared in high enantiomeric purity from racemic t-butyloxirane (+/-)-3 by an enzymatic route. (S)-3 has been used for the preparation of the chiral β-amino alcohols (R)- and (S)-1,2, which are catalysts for the enantioselective addition of dialkylzinc reagents to aldehydes.

Remote Amino Acid Recognition Enables Effective Hydrogen Peroxide Activation at a Manganese Oxidation Catalyst

Precise delivery of a proton plays a key role in O2 activation at iron oxygenases, enabling the crucial O?O cleavage step that generates the oxidizing high-valent metal–oxo species. Such a proton is delivered by acidic residues that may either

Aromatic Donor-Acceptor Interaction-Based Co(III)-salen Self-Assemblies and Their Applications in Asymmetric Ring Opening of Epoxides

Aromatic donor-acceptor interaction as the driving force to assemble cooperative catalysts is described. Pyrene/naphthalenediimide functionalized Co(III)-salen complexes self-assembled into bimetallic catalysts through aromatic donor-acceptor interactions and showed high catalytic activity and selectivity in the asymmetric ring opening of various epoxides. Control experiments, nuclear magnetic resonance (NMR) spectroscopy titrations, mass spectrometry measurement, and X-ray crystal structure analysis confirmed that the catalysts assembled based on the aromatic donor-acceptor interaction, which can be a valuable noncovalent interaction in supramolecular catalyst development.

Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.