1438-55-7

Usage

Uses

Used in Organic Synthesis:
(1S,βS)-1,4,4aα,5,6,7,8,8a-Octahydro-β,2,5,5,8aβ-pentamethyl-1β-naphthalenepentanoic acid methyl ester is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows it to be a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Applications:
Due to its complex structure and the presence of a naphthalene ring, (1S,βS)-1,4,4aα,5,6,7,8,8a-Octahydro-β,2,5,5,8aβ-pentamethyl-1β-naphthalenepentanoic acid methyl ester may have potential pharmaceutical applications. Further research and investigation would be required to explore its biological activity and potential use as a drug candidate or in the development of drug delivery systems.
Used in Chemical Research:
(1S,βS)-1,4,4aα,5,6,7,8,8a-Octahydro-β,2,5,5,8aβ-pentamethyl-1β-naphthalenepentanoic acid methyl ester can be utilized in chemical research to study the effects of its structural features on various chemical and biological properties. This may include investigations into its reactivity, stability, and interactions with other molecules, which could lead to new insights and applications in the field of chemistry.

Upstream product

• 87563-31-3 (S)-3-Methyl-5-[(1S,4aR,6S,8aR)-2,5,5,8a-tetramethyl-6-((Z)-2-methyl-but-2-enoyloxy)-7-oxo-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl]-pentanoic acid methyl ester 
• 10267-25-1 methyl (5S,8R,9R,10S,13S)-8-hydroxylabdan-15-oate 
• 468-82-6 (-)-(5S,9S,10S,13S)-labd-7-en-15-oic acid 
• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 
• 110876-92-1 labd-7-en-15-oic acid 
• 88333-02-2 diazomethane 
• 24460-82-0 labd-8⁽¹⁷⁾-en-15-oic acid 
• 99831-26-2 labd-8-en-15-oic acid 

Relevant academic research and scientific papers

3α-ANGELOYLOXY-2α-HYDROXYCATIVIC ACID, A NEW DITERPENE FROM BRICKELLIA PANICULATA

The investigation of Brickellia paniculata resulted in the isolation of a new diterpene of the labdane type.It was identified as 3α-angeloyloxy-2α-hydroxycativic acid by chemical and spectroscopic methods. - Key Word Index: Brickellia paniculata; Compositae; diterpene; 3α-angeloyloxy-2α-hydroxycativic acid.

COMPOSITION FOR PREPARATION FOR EXTERNAL USE ON SKIN AND METHOD OF USING THE SAME

Disclosed is a composition containing a compound represented by formula (1) below, and a particular class ingredient. In formula (1), R1 represents -CH2OH or COOR6, R6 represents hydrogen, lower alkyl group having the number of carbon atoms of 1 to 3 or cation capable of forming a salt with COO-, each of R2 to R5 independently represents a hydrogen atom or methyl group, and ··· A··· represents =C(CH3)-, -C(CH3)=, -C(=CH2)-, -CH(CH3)- or -C (OH) (CH3)-.

Cell growth activating composition containing compound having labdane structure

The present invention provides compounds which have, particularly, an inhibitory activity on production of melanin, a cell activating activity and an anti-bacterial activity, are derived from natural sources, and are safe and not harmful. One or more compounds represented by the following general formula are contained: wherein R1represents —CH2OH, —COOR6or —COOX, whereupon X is a group capable forming a salt and R6represents hydrogen or a C1to C3lower alkyl group; R2to R5each represent hydrogen or a methyl group; and . . . A . . . represents ═C(CH3)—, —C(CH3)═, —C(═CH2)—, —CH(CH3)— or —C(OH)(CH3)—.

Regioselective dehydration of axial and equatorial tertiary alcohols with α-methyl group in the cyclohexane ring by Swern's reagent

Swern's reagent (a complex of oxalyl chloride with DMSO) was shown to dehydrate tertiary alcohols containing an α-methyl group in the cyclohexane ring. Dehydration of equatorial alcohols affords mixtures of isomeric compounds where isomers with an exocyclic double bond dominate, whereas isomers with an endocyclic double bond prevail in the products of dehydration of axial tertiary alcohols. Thus, Swern's reagent can serve as a chemical test to determine the configuration of tertiary alcohols containing an α-methyl group in cyclohexane ring. The composition of the products of dehydration of these alcohols with Swern's reagent is similar to that obtained by their dehydration with POCl3 in pyridine.

REACTIVITY OF METHYL LABDANOLATE WITH LEAD TETRAACETATE

The reactivity of the methyl labdanolate, 3 with Pb(OAc)4 and/or Pb(OAc)4/I2 was studied.The long distance functionalization at C-12 led to compounds 8b and 9b, whose oxidation with RuO4 produced 16 at a 100percent yield.Compounds 14 and 15 were obtained

LABDANE DITERPENOIDS FROM CISTUS LABDANIFERUS

Three new diterpenic acids have been isolated from Cistus ladaniferus: 6,8(17) labdadien-15-oic, 7-oxo-8-labden-15-oic and 6β-acetoxy-7-oxo-8-labden-15-oic acids, beside labdanolic, 6-oxocavitic, 7α-hydroxy-8(17)-labden-15-oic, 8α-methoxy-labda-15-oic and 8α-hydroxy-13(E)-labden-15-oic acids.Key Word Index - Cistus ladaniferus; Cistaceae; diterpenic acids.