10267-25-1 Usage
Uses
Used in Organic Synthesis:
(1R,4aα,βS)-Decahydro-2α-hydroxy-β,2,5,5,8aβ-pentamethyl-1-naphthalenepentanoic acid methyl ester is used as a synthetic intermediate for the preparation of various organic compounds due to its complex structure and functional groups.
Used in Pharmaceutical Industry:
(1R,4aα,βS)-Decahydro-2α-hydroxy-β,2,5,5,8aβ-pentamethyl-1-naphthalenepentanoic acid methyl ester is used as a potential pharmaceutical candidate for the development of new drugs, given its unique structure and functional groups that may offer novel therapeutic properties.
Used in Materials Science:
(1R,4aα,βS)-Decahydro-2α-hydroxy-β,2,5,5,8aβ-pentamethyl-1-naphthalenepentanoic acid methyl ester is used as a component in the development of new materials with specific properties, such as improved stability or reactivity, owing to its complex structure and functional groups.
Further research and investigation into the properties and potential uses of (1R,4aα,βS)-Decahydro-2α-hydroxy-β,2,5,5,8aβ-pentamethyl-1-naphthalenepentanoic acid methyl ester are necessary to fully understand its significance and unlock its full potential in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 10267-25-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,6 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10267-25:
(7*1)+(6*0)+(5*2)+(4*6)+(3*7)+(2*2)+(1*5)=71
71 % 10 = 1
So 10267-25-1 is a valid CAS Registry Number.
10267-25-1Relevant academic research and scientific papers
Evaluation of labdane derivatives as potential anti-inflammatory agents
Girón, Natalia,Pérez-Sacau, Elisa,López-Fontal, Raquel,Amaro-Luis, Juan M.,Hortelano, Sonsoles,Estevez-Braun, Ana,De Las Heras, Beatriz
experimental part, p. 3155 - 3161 (2010/08/22)
In the present study, a series of labdane derivatives (2-9) were prepared from labdanediol (1) and their potential as anti-inflammatory agents were evaluated on lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. All compounds were able to inhibit LPS-induced nitric oxide (NO), although compounds 1, 2, 5, 8 and 9 exhibited the most potent effects with a range of IC 50 values of 5e15 mM. Similarly to the inhibitory effects on NO release, these labdane derivatives also inhibited prostaglandin E2 (PGE 2) production. However, analysis of cell viability demonstrated that effects on NO release and (PGE2) production of compounds 1, 8 and 9 were due to citotoxicity, whereas compound 2 and 5 did not show any effect in the survival of RAW 264.7 macrophages. In addition to these in vitro data, compound 5 also showed anti-inflammatory activity in vivo, when tested in mice. They prevented the extent of swelling in the TPA-induced ear edema model and inhibited MPO activity, showing similar potency to that of the widely used anti-inflammatory drug indomethacin. These results indicate that compound 2 and in particular compound 5 might be used for the design of new anti-inflammatory agents.
