1438-58-0

Usage

Uses

Used in Drug Discovery:
(2R,5S)-4,4'aα,5,5',6',7',8',8'a-Octahydro-2',5,5',5',8'aβ-pentamethylspiro[furan-2(3H),1'(4'H)-naphthalene]-5-acetic acid methyl ester is used as a potential candidate in drug discovery for its unique structure and properties that may offer novel therapeutic effects and mechanisms of action.
Used in Material Science:
In the field of material science, (2R,5S)-4,4'aα,5,5',6',7',8',8'a-Octahydro-2',5,5',5',8'aβ-pentamethylspiro[furan-2(3H),1'(4'H)-naphthalene]-5-acetic acid methyl ester is utilized for its potential to contribute to the development of new materials with specific characteristics, such as improved stability, reactivity, or selectivity in various chemical processes.

Upstream product

• 186581-53-3 diazomethane 
• 1438-57-9 (-)-grindelic acid 
• 1438-57-9 grindelic acid 

Downstream Products

• 1456515-66-4 4-(3-ethynylphenyl)-1-(2-((1'R,5S,8a'S)-2',5,5',5',8a'-pentamethyl-4,4a',5,5',6',7',8',8a'-octahydro-3H,4'H-spiro[furan-2,1'-naphthalene]-5-yl)ethyl)-1H-1,2,3-triazole 
• 1438-57-9 (-)-grindelic acid 

Relevant academic research and scientific papers

Derivatives of grindelic acid: From a non-active natural diterpene to synthetic antitumor derivatives

Using several reactions that include homologations and asymmetric epoxidations as well as Ugi and Huisgen couplings, we generated a small focused library of new derivatives from the labdane-type diterpene grindelic acid. These compounds were evaluated as cytotoxic agents against a panel of five human solid tumor cell lines (HBL-100, HeLa, SW1573, T-47D, and WiDr). The presence of the diamide functionalizations enhanced the cytotoxic effect. N-Benzyl-N-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)grindelicamide, proved to be the most active product in all cell lines tested, with values of 0.95 (±0.38) μM against HBL-100 cells. 2013 Elsevier Masson SAS. All rights reserved.

Absolute Stereochemistry of the Novel Dioxaspiro Diterpenoids Strictanonic and Grindelistrictic Acids. Stereoselective Synthesis of Strictanonic Acid Methyl Ester and its C-6 Epimer

The stereoselective synthesis of (+)-strictanonic acid methyl ester (2b) and its C-6 epimer from a common chiral intermediate, derived from natural grindelic acid (1a) of known absulute configuration, is described.With the aid of one- and two-dimensional multipulse n.m.r. techniques, the complete stereochemistry of strictanonic acid and that of C-9 of the related bisnorditerpene grindelistrictic acid (6a) was established.