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1438-57-9

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  • 2-[(2'S,4aS,8R,8aS)-2',4,4,7,8a-pentamethylspiro[2,3,4a,5-tetrahydro-1H-naphthalene-8,5'-oxolane]-2'-yl]acetic acid

    Cas No: 1438-57-9

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1438-57-9 Usage

Uses

(-)-Grindelic Acid is a natural diterpene with potential pharmaceutical applications including Nox4 inhibition and antitumor activity.

Check Digit Verification of cas no

The CAS Registry Mumber 1438-57-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,3 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1438-57:
(6*1)+(5*4)+(4*3)+(3*8)+(2*5)+(1*7)=79
79 % 10 = 9
So 1438-57-9 is a valid CAS Registry Number.

1438-57-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (-)-grindelic acid

1.2 Other means of identification

Product number -
Other names GRINDELIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1438-57-9 SDS

1438-57-9Downstream Products

1438-57-9Relevant articles and documents

Stereocontrolled synthesis of ent-grindelic acid. A useful example of diastereofacial guidance in an oxonium ion-initiated pinacolic ring expansion

Paquette, Leo A.,Wang, Hui-Ling

, p. 5352 - 5357 (2007/10/03)

An enantioselective synthesis of (+)-grindelic acid is described, confirming that the dextrorotatory enantiomer is antipodal to the natural diterpenoid. The optically pure bicyclic ketone 5 representing the AB ring system is constructed from the levorotatory Wieland-Miescher ketone and must therefore possess the absolute configuration shown. Coupling of 5 with the 5-lithio derivative of optically active 2,3-dihydrofuran 3 derived from (R)-(-)-linalool was effected for the purpose of realizing acid-catalyzed rearrangement with generation of the appropriate spirocyclic framework. This key step is highly stereocontrolled, leading predominantly to 7. Once the advanced intermediate 15 is available in this fashion, its subsequent exposure to oxidation and dehydration steps led to the target molecule. The synthesis demonstrates unequivocally that natural (-)-grindelic acid is a true labdane diterpenoid.

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