1438395-04-0

Basic information

• Product Name: C₈H₁₄O₇
• CAS NO: 1438395-04-0
• Molecular Weight: 222.195
• Mol File: 1438395-04-0.mol

Chemical Properties

• CAS DataBase Reference: C₈H₁₄O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₁₄O₇(1438395-04-0)
• EPA Substance Registry System: C₈H₁₄O₇(1438395-04-0)

Safety Data

• Hazardous Substances Data: 1438395-04-0(Hazardous Substances Data)

Upstream product

• 530-26-7 D-Mannose 
• 75-36-5 acetyl chloride 

Downstream Products

• 74808-09-6 2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl trichloroacetimidate 
• 1373416-77-3 (2S)-3-cyclohexyl-2-[2-hydroxy-1-(2,3,4,6-tetra-O-benzyl-α-D-mannpyranosyl)naphthalen-7-yloxy]propionic acid methyl ester 
• 1373416-80-8 (2S)-3-cyclohexyl-2-[2-hydroxy-1-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)naphthalen-7-yloxy]propionic acid 
• 1373416-82-0 (2S)-3-cyclohexyl-2-[2-hydroxy-1-(-D-mannopyranosyl)naphthalen-7-yloxy]propionic acid 
• 1373416-86-4 (2S)-3-cyclohexyl-2-[2-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyloxy)naphthalen-7-yloxy]propionic acid methyl ester 
• 1373416-84-2 (2S)-3-cyclohexyl-2-[2-hydroxy-1-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)naphthalen-7-yloxy]propionic acid methyl ester 
• 3866-62-4 1-O-acetyl-2,3,4,6-tetra-O-benzyl-D-mannopyranose 

Relevant articles and documents

Monosaccharidic mimetics of the sialyl LewisX tetrasaccharide based on 2,7-dihydroxynaphthalene

A potential monosaccharidic mimetic of the sialyl LewisX tetrasaccharide (sLeX) was identified based on an in silico docking study using the crystal structure of an E-selectin-sLeX complex. The chemical synthesis of the mimetic in an ortho-selective C-glycosylation is described. This compound and two close analogues were evaluated in a cell-based selectin binding assay where none of the tested mimetics showed an IC 50 below 1mM. This result can be explained by an unexpected 1C4 conformation of the mannosyl residue which precludes the required binding of the Ca2+-ion in E-selectin.