1438408-08-2

Upstream product

• 1817-49-8 1,3-diphenyl-1-propyn-3-ol 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 

Downstream Products

• 1145-01-3 3,5-Diphenylpyrazole 
• 1575-27-5 3,5-diphenyl-1-(p-toluenesulfonyl)-1H-pyrazole 
• 1385069-09-9 3,5-diphenyl-1-(prop-2-yn-1-yl)-1H-pyrazole 

Relevant academic research and scientific papers

Facile one-pot synthesis of 3,5-disubstituted 1 h -pyrazoles from propargylic alcohols via propargyl hydrazides

A new and efficient metal-free, two-component, one-pot approach to a variety of 3,5-disubstituted 1H-pyrazoles has been developed from propargylic alcohols. This transformation proceeds via an acid-catalyzed propargylation of N,N-diprotected hydrazines followed by base-mediated 5-endo-dig cyclization leading to 3,5-disubstituted 1H-pyrazoles in good overall yields. Georg Thieme Verlag Stuttgart. New York.

Propargyl hydrazides: Synthesis and conversion into pyrazoles through hydroamination

Pyrazoles direct: Propargyl alcohols undergo hydrazination when treated with p-tosyl hydrazide in the presence of catalytic amounts of either Sc(OTf)3 or La(OTf)3 (see scheme; Tf= trifluoromethanesulfonyl). Propargyl hydrazides are converted into either N-tosyl or N-H pyrazoles when treated with an acid or a base, respectively. The one-step acid-catalyzed hydrazination/cyclization of propargyl alcohols directly affords pyrazoles in high yields. Copyright