14386-72-2Relevant academic research and scientific papers
1-phenyl-3-benzenemethylamido-2-propylene-1-ketone compounds and preparation method and use thereof
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, (2017/08/30)
The invention provides 1-phenyl-3-benzenemethylamido-2-propylene-1-ketone compounds and a preparation method and use thereof. The compounds are a series of compounds with brand-new structures, have a very good inhibitory effect on aggregation of A beta protein, meanwhile, can also be used for inhibiting the aggregation of Tau proteins and can be used for developing drugs for treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Conjugate addition of isocyanides to chromone 3-carboxylic acid: An efficient one-pot synthesis of chroman-4-one 2-carboxamides
Neo, Ana G.,Diaz, Jesus,Marcaccini, Stefano,Marcos, Carlos F.
experimental part, p. 3406 - 3416 (2012/05/20)
We report a novel Lewis acid catalysed tandem reaction of isocyanides, chromone 3-carboxylic acid and nucleophiles. An experimentally very simple procedure, involving the use of microwave irradiation in the presence of a Lewis acid catalyst, affords a representative collection of chromone-2-carboxamides and chromone-2-carboxamido-3-esters in high yields, in just a few minutes. Such an unprecedented strategy is formally equivalent to a conjugate addition of isocyanides to Michael acceptors.
