143869-99-2Relevant articles and documents
An approach toward the total synthesis of cyclotheonamides; preparation of a C(1) to N(14) segment
Wipf, Peter,Kim, Hong-Yong
, p. 4275 - 4278 (2007/10/02)
The C(1) to N(14) segment of the potent thrombin inhibitor cyclotheonamide A was prepared from L-arginine, L-proline, and L-asparagine. The arginine backbone was extended via a cyanohydrin, and the usual diaminopropanoic acid residue was obtained from hypervalent iodine oxidation of the asparagine side chain.