143879-80-5

Basic information

• Product Name: 2,3,4-Trifluorobenzonitrile
• Synonyms: 2,3,4-carbonitrile;2,3,4-TRIFLUOROBENZONITRILE;Benzonitrile, 2,3,4-trifluoro- (9CI);3-flurobenzoyl chloride;2,3,4-Trifluorobenzonitrile 98%;2,3,4-Trifluorobenzonitrile98%
• CAS NO: 143879-80-5
• Molecular Formula: C₇H₂F₃N
• Molecular Weight: 157.09
• EINECS: -0
• Product Categories: HALIDE;Fluorobenzene Series;FINE Chemical & INTERMEDIATES;Fluorobenzene;Nitrile
• Mol File: 143879-80-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 95-99C
• Boiling Point: 116-118 °C100 mm Hg(lit.)
• Flash Point: 155 °F
• Appearance: clear slightly yellow to light brown liquid
• Density: 1.12 g/mL at 25 °C(lit.)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: n20/D 1.4725(lit.)
• Storage Temp.: 2-8°C
• BRN: 5427682
• CAS DataBase Reference: 2,3,4-Trifluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-Trifluorobenzonitrile(143879-80-5)
• EPA Substance Registry System: 2,3,4-Trifluorobenzonitrile(143879-80-5)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-36-36/37-9
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 143879-80-5(Hazardous Substances Data)

Usage

Chemical Properties

clear slightly yellow to light brown liquid

InChI:InChI=1/C13H11FO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9,13,15H

Upstream product

• 157373-08-5 2,3,4-trifluoro-benzoyl chloride 
• 207919-09-3 2,3,4-trifluorobenzamide 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 

Downstream Products

• 1401998-80-8 3-fluoro-2,4-dihydroxybenzaldehyde 
• 1374968-91-8 (R)-2-(4-cyano-2,3-difluorophenylamino)-4-methylpentanamide 
• 1374968-90-7 (R)-4-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-fluoro-2-(3-methylisothiazol-5-ylamino)benzamide 
• 1372123-26-6 C₂₃H₁₇F₃N₂O₂ 
• 1189353-15-8 4-(dimethylamino)-2,3-difluorobenzonitrile 
• 1073973-12-2 N'-(4-cyano-2,3-difluoro-phenyl)-hydrazinecarboxylic acid tert-butyl ester 
• 780769-44-0 (6-cyano-2,3-difluoro-phenyl)-acetic acid ethyl ester 
• 706805-37-0 6,7-difluoro-1H-indazole-3-amine 
• 845616-26-4 4-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 780769-51-9 2-(6-cyano-2,3-difluorophenyl)malonic acid diethyl ester 
• 235088-67-2 (2,3,4-trifluorophenyl)methanamine 

Relevant articles and documents

Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening

As part of a search for a substrate for droplet-based microfluidic screening assay of α-N-acetylgalactosaminidases, spectral and physical characteristics of a series of coumarin derivatives were measured. From among these a new coumarin-based fluorophore, Jericho Blue, was selected as having optimal characteristics for our screen. A reliable method for the challenging synthesis of coumarin glycosides of α-GalNAc was then developed and demonstrated with nine examples. The α-GalNAc glycoside of Jericho Blue prepared in this way was shown to function well under screening conditions.