143896-78-0

Basic information

• Product Name: C₁₁H₁₁N₃O₂S₂
• Synonyms: C₁₁H₁₁N₃O₂S₂
• CAS NO: 143896-78-0
• Molecular Weight: 281.359
• Mol File: 143896-78-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₁N₃O₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₁N₃O₂S₂(143896-78-0)
• EPA Substance Registry System: C₁₁H₁₁N₃O₂S₂(143896-78-0)

Safety Data

• Hazardous Substances Data: 143896-78-0(Hazardous Substances Data)

Upstream product

• 10200-59-6 Thiazole-2-carbaldehyde 
• 3619-22-5 p-toluic hydrazide 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 143896-82-6 C₁₂H₁₃N₃O₂S₂ 

Relevant articles and documents

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker

Target-identification phenotypic screening has been a powerful approach in drug discovery; however, it is hindered by difficulties in identifying the underlying cellular targets. To address this challenge, we have combined phenotypic screening of a fully functionalized small-molecule library with competitive affinity-based proteome profiling to map and functionally characterize the targets of screening hits. Using this approach, we identified ANXA2, PDIA3/4, FLAD1, and NOS2 as primary cellular targets of two bioactive molecules that inhibit cancer cell proliferation. We further demonstrated that a panel of probes can label and/or image annexin A2 (a cancer biomarker) from different cancer cell lines, thus providing opportunities for potential cancer diagnosis and therapy.

SYNTHESIS OF THIAZOLOTRIAZOLES A NEW RING-FUSED HETEROCYCLE

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