143915-13-3

Upstream product

• 7732-18-5 water 
• 20859-02-3 L-tert-Leucine 
• 501-53-1 benzyl chloroformate 
• 141970-45-8 (S)-2-benzyloxycarbonylamino-3,3-dimethyl-butyric acid methyl ester 
• 848777-16-2 benzyl N-[(1S)-1-(hydroxymethyl)-2,2-dimethyl-propyl]carbamate 

Downstream Products

• 143914-87-8 (E)-(R)-4-Benzyloxycarbonylamino-2,5,5-trimethyl-hex-2-enoic acid ethyl ester 
• 239135-76-3 (5S,1'S,2'S)-5-[1-(benzyloxycarbonylamino)-2,2-dimethylpropyl]-3-methylenedihydro-2(3H)-furanone 
• 241149-84-8 (2'S,3'S)-methyl 2-[3-(benzyloxycarbonylamino)-2-hydroxy-4,4-dimethylpentyl]propenoate 

Relevant academic research and scientific papers

PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF

This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

Synthesis of novel amino-acid-derived sulfinamides and their evaluation as ligands for the enantioselective transfer hydrogenation of ketones

Novel chiral mono-sulfinyl diamines bearing a stereogenic sulfur atom were prepared in moderate to good yields starting from amino acids by means of a reductive amination of the corresponding amino aldehydes. Their potential as ligands for asymmetric catalysis was evaluated in the metal-catalyzed enantioselective transfer hydrogenation of alkyl-aryl ketones. The catalysts were generated in situ from sulfinamides 1a-i and arene complexes of rhodium and ruthenium, and the catalytic reductions led to the formation of chiral alcohols with up to 91% ee. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Aminoalkyl-substituted α-methylene-γ-butyrolactones from α-amino acids using an indium-mediated Barbier allyl addition

The indium-mediated reaction of Z-protected α-amino aldehydes 1-6 with 2-(bromomethyl)acrylates 8/9 in aqueous solvents has been investigated. The preference for the formation of syn-configured homoallyl alcohols 10-16 (diastereoselectivities ranging from

CYTOKINE INHIBITING IMIDAZOLE SUBSTITUTED HYDROXAMIC ACID DERIVATIVES

The present invention relates to a series of novel imidazole substituted hydroxamic acid derivatives, and compositions useful thereof as inhibitors of matrix degrading metalloproteinases, in particular collagenase.

Stereoselective silver triflate-mediated iodocyclization of carbamates

Iodocyclization of carbamates involving electron-deficient olefins, (i.e. α,β-unsaturated esters) is greatly facilitated by the use of silver(l) triflate and proceeds with excellent trans ring stereoselectivity. During this process, the resultant iodides can undergo epimerization, the rate of which is solvent-dependent.

ALUMINUM-MEDIATED ONE-POT CONVERSION OF α-AMINO ACID ESTERS TO THREO 2-AMINO ALCOHOLS WITH HIGH DIASTEREOSELECTIVITY

Reduction of N-Cbz α-amino acid esters with DIBAl-H, followed by treatment with Grignard reagent in a one-pot manner gave the corresponding threo 2-amino alcohols with high diastereoselectivity without racemization. KEYWORDS 2-amino alcohol; α-amino acid ester; DIBAL-H reduction; α-amino aldehyde; chelation controll; diastereoselective synthesis; one-pot synthesis