848777-16-2

Upstream product

• 62965-10-0 (S)-N-carbobenzoxy-tert-butylleucine 
• 112245-13-3 (S)-tert-leucinol 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 143915-13-3 Z-Tle-H 
• 239135-76-3 (5S,1'S,2'S)-5-[1-(benzyloxycarbonylamino)-2,2-dimethylpropyl]-3-methylenedihydro-2(3H)-furanone 
• 241149-84-8 (2'S,3'S)-methyl 2-[3-(benzyloxycarbonylamino)-2-hydroxy-4,4-dimethylpentyl]propenoate 
• 143914-87-8 (E)-(R)-4-Benzyloxycarbonylamino-2,5,5-trimethyl-hex-2-enoic acid ethyl ester 
• 848777-17-3 C₁₅H₂₃NO₅S 
• 1007121-77-8 (S)-3-(benzyloxycarbonyl)-4-tert-butyl-[1,2,3]oxathiazolidine 2,2-dioxide 

Relevant academic research and scientific papers

Synthesis of 2,6-disubstituted piperazines by a diastereoselective palladium-catalyzed hydroamination reaction

(Chemical Equation Presented) A highly diastereoselective intramolecular hydroamination is the key step in a modular synthesis of 2,6-disubstituted piperazines. The requisite hydroamination substrates were prepared in excellent yields by nucleophilic disp

Synthesis of novel amino-acid-derived sulfinamides and their evaluation as ligands for the enantioselective transfer hydrogenation of ketones

Novel chiral mono-sulfinyl diamines bearing a stereogenic sulfur atom were prepared in moderate to good yields starting from amino acids by means of a reductive amination of the corresponding amino aldehydes. Their potential as ligands for asymmetric catalysis was evaluated in the metal-catalyzed enantioselective transfer hydrogenation of alkyl-aryl ketones. The catalysts were generated in situ from sulfinamides 1a-i and arene complexes of rhodium and ruthenium, and the catalytic reductions led to the formation of chiral alcohols with up to 91% ee. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

SULFUR COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

Stereoselective silver triflate-mediated iodocyclization of carbamates

Iodocyclization of carbamates involving electron-deficient olefins, (i.e. α,β-unsaturated esters) is greatly facilitated by the use of silver(l) triflate and proceeds with excellent trans ring stereoselectivity. During this process, the resultant iodides can undergo epimerization, the rate of which is solvent-dependent.